53 applicants
Johnson & Johnson · 4 days ago
Senior Scientist, Protein Design
Cambridge, MA
Full-time
Onsite
Senior Level
$113K/yr - $196K/yr
2+ years exp
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Responsibilities
Work directly with wet-lab scientists and therapeutic areas to design and optimize protein molecules for specific functions and properties.
Collaborate with team members across Therapeutics Discovery on the planning, prioritization, and timely delivery of designs to support multiple concurrent programs.
Serve as an In Silico Discovery Lead on diverse project teams.
Work with ML colleagues to guide development, benchmarking, and application of pioneering generative and discriminative models.
Model sophisticated biological systems using a variety of methods and tools to advise design methodology.
Participate in internal and external presentations, peer-reviewed manuscripts and conference proceedings.
Qualification
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Required
PhD in Computational Biology (or other related field), with at least 2 years of relevant experience is required.
Extensive experience in computational protein modeling, design, structural biology, and biophysics is required.
Experience leading projects in cross-functional teams to completion in a collaborative manner is required.
Experience with high performance computing (on-prem or cloud) is required.
Advanced proficiency in Python and related data-science packages such as Pandas and Numpy is required.
Excellent communication, reporting and team interaction skills, self-motivated, proactive, and independent.
Desire for continuous learning and the ability to identify, evaluate and deploy emerging algorithms, models, and protein design workflows is required
Preferred
Experience interacting with protein engineers in an academic or industrial setting or equivalent experience is preferred.
Experience in de novo protein design and sophisticated protein design techniques is preferred. Examples may include; large scale backbone editing, fusion design, loop design (inpainting), deletions, and extensions.
Knowledge of critical wet-lab techniques used in protein engineering such as yeast display, SPR, ITC, CD-spectroscopy is preferred.
Solid understanding of current machine learning architectures is preferred.
Experience with powerful ML packages for protein modeling and design such as AlphaFold, RosettaFold, ESMFold, ProteinMPNN, RFDiffusion, Chroma, IgFold, DeepAb, Parapred, etc is preferred.
Experience with retraining, fine-tuning, and building ML models such as LLMs to support advanced protein design and protein property prediction tools is preferred.
Experience with Schrodinger, FoldX, Rosetta, Discovery Studio, MOE, GROMACS, NAMD or other molecular dynamics simulation software is preferred.
Travel up to 10% may be required.
Benefits
Medical
Dental
Vision
Life insurance
Short- and long-term disability
Business accident insurance
Group legal insurance
Retirement plan (pension)
Savings plan (401(k))
Vacation
Sick time
Holiday pay
Work, Personal and Family Time
Company
Johnson & Johnson
Johnson & Johnson develops medical devices, pharmaceuticals, and consumer packaged goods.
10,001+ employees
H1B Sponsorship
Johnson & Johnson has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Trends of Total Sponsorships
2023 (43)
2022 (55)
2021 (40)
2020 (30)
Funding
Current Stage
Public CompanyTotal Funding
unknown1978-01-13IPO· nyse:JNJ
Leadership Team
Alex Gorsky
Chairman & CEO
Dominic J. Caruso
Vice President, Finance and Chief Financial Officer
Recent News
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