Be an early applicantLess than 25 applicants

Company

Original Job Post

Johnson & Johnson · 6 days ago

Principal Scientist, Discovery - Ocular Genetics

Cambridge, MA

Full-time

Hybrid

Senior Level

$113K/yr - $196K/yr

3+ years exp

Wonder how qualified you are to the job?

Maximize your interview chances

Health CareMedical Device

H1B Sponsorship

Comp. & Benefits

Insider Connection @Johnson & Johnson

Discover valuable connections within the company who might provide insights and potential referrals, giving your job application an inside edge.

Responsibilities

Identify novel ocular therapeutic targets and biomarkers through investigation of human genetic association with disease.

Leverage large-scale biobanks, GWAS, mendelian genetics, and other data sources for discovery and interpretation.

Develop and apply methods for integrating GWAS results with other data types for causal inference and fine mapping.

Collaborate with interdisciplinary teams to address mechanism-specific questions and support decision-making through genomic insight.

Uncover opportunities for therapeutic translation and biomarkers of disease heterogeneity, progression, and treatment response from genetic data sources.

Qualification

Find out how your skills align with this job's requirements. If anything seems off, you can easily click on the tags to select or unselect skills to reflect your actual expertise.

Genomic discoveryGWASWES/WGS datasetsElectronic health recordPhenotype evaluationImputationStatistical computingR programmingGenetic analysisPLINKHAILEPACTSMETAL/RAREMETALManaging workflowsProject managementManuscript writingPeer-reviewed publicationsOral presentationsData analysisTechnical expertiseBiologyComputational toolsProblem-solvingCollaborationVerbal communicationWritten communicationInterpersonal skillsTime managementOrganizational skillsFine-scale locus dissection

Required

PhD in the field of statistical genetics, bioinformatics, epidemiology or biostatistics with postdoctoral experience and 3+ years of experience in an industry research environment

Track record of genomic discovery in large scale GWAS and WES/WGS datasets in academia and/or industry with electronic health record derived phenotypes highly desired

Knowledge and experience examining the range of genome-wide and phenome-wide analysis approaches, encompassing genotype and sample q.c., phenotype evaluation, imputation, and methods to address relatedness, population structure, case-control imbalance in large WES/WGS and GWAS datasets

Experience with statistical computing in R expected with familiarity of aggregated marker methods (e.g. burden, SKAT, VT) and large-scale genetic analysis approaches (e.g. PLINK, HAIL, EPACTS, METAL/RAREMETAL)

Strong proficiency in managing workflows, priorities, and deadlines and managing multiple projects as part of a small team

Highly motivated and demonstrated ability to work in a collaborative environment

Ability to write manuscripts for publication and has maintained a record of high-quality peer reviewed publications and oral presentations in a relevant field

Strong analytical and problem-solving skills, as well as organizational and time management skills

Demonstrated excellent verbal and written communication skills

Demonstrated interpersonal skills with the ability to work effectively with an interdisciplinary team, including laboratory scientists, bioinformaticians, statisticians, and data analysts

Provide ad hoc training and help to biology teams on the use of computational tools, data analyses and interpretation; provide technical expertise for emerging technologies and approaches

Preferred

Experience in fine-scale locus dissection and in causal inference from individual-level and summary association data a plus

Familiarity with Ophthalmology human genetics and biology, target identification and therapeutic development a plus

Knowledge of biological mechanisms of human genetic diseases and application of computational biology methods (preferably in the biotech/pharmaceutical industry) desired

Benefits

Health insurance

Savings plan

Pension plan

Disability plan

Long term incentives

Vacation pay

Sick time

Holiday pay

Work, personal, and family time off

Company

Johnson & Johnson

Glassdoor

4.2

Johnson & Johnson develops medical devices, pharmaceuticals, and consumer packaged goods.

Founded in 1886

New Brunswick, New Jersey, USA

10,001+ employees

http://www.jnj.com

H1B Sponsorship

Johnson & Johnson has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Trends of Total Sponsorships

2023 (43)

2022 (55)

2021 (40)

2020 (30)