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Company

Original Job Post

Senti Biosciences · 3 days ago

Senior Scientist, Process Development

South San Francisco, CA

Full-time

Onsite

Senior Level

$165K/yr - $180K/yr

6+ years exp

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BiotechnologyHealth Care

H1B Sponsorship

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Responsibilities

Play a key role in process development for Senti's cell therapy development programs, with focus on culture expanded allogeneic products, including natural killer cells (NKs) and other therapeutic cell modalities

Work closely with the CDMO MSAT team to understand key requirements and guide decision making to enable seamless transfers and process optimizations

Develop internal capability for larger scale bioreactor-based generation of genetically modified cells suitable for transfer to a GMP facility.

Play a central role in selection and interaction with contract manufacturers, key suppliers, and other external vendors

Maintain thought leadership with the current cell therapy ecosystem and bring best practices to the organization

Coordinate tasks across multiple projects. Make decisions on prioritization and planning. Be the key driver to meet project timelines and milestones

Lead in design, development, and execution of process development studies to aid in optimization and characterization of cell manufacturing processes

Apply knowledge of immune cell biology to establish process robustness yield high quality cells

Review executed batch records, extract and trend data, and identify areas for improvement

Support regulatory filings through authorship and review of technical sections

Qualification

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Cell Therapy Process DevelopmentImmunology CellsLentiviral VectorsRetroviral VectorsEx Vivo Cell EngineeringIND Regulatory RequirementsGMP EnvironmentsQuality DocumentationMulti-Functional Project ManagementProblem-SolvingIndependence

Required

BS/BA degree with 8+ years experience or MS/PhD degree with 6+ years experience in a cell therapy development setting

4+ years of cell therapy process development experience from proof-of-concept to clinical manufacturing, preferably with immunology cells (NKs, T, HSCs, etc.)

Experience with lentiviral, retroviral, and other ex vivo cell engineering vectors a plus

Familiarity with IND regulatory requirements, GMP environments, and quality documentation

Demonstrated ability to work independently in a multi-functional project at a fast moving organization

Benefits

Equity

Company

Senti Biosciences

Senti Biosciences is a developer of a programmable biology platform for cancer therapies.

Founded in 2016

South San Francisco, California, USA

51-200 employees

https://www.sentibio.com/

H1B Sponsorship

Senti Biosciences has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Trends of Total Sponsorships

2023 (6)

2022 (2)

2021 (1)

2020 (2)