93 applicants

Company

Original Job Post

AstraZeneca · 2 days ago

Scientist, Oncology Bioscience

Waltham, MA

Full-time

Onsite

Entry, Mid Level

3+ years exp

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Comp. & Benefits

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Responsibilities

Design, conduct, and analyze in vitro experiments to assess the function of candidate oncology drugs and dissect the mechanism of action of novel therapeutics.

Review emerging literature and internal data to identify new targets and contribute to target validation activities.

Establish assay systems and deliver datasets impacting targeted therapeutics.

Work independently and collaboratively to execute assigned tasks in alignment with project goals.

Report data clearly and concisely, understanding its implications within the context of drug discovery.

Qualification

Find out how your skills align with this job's requirements. If anything seems off, you can easily click on the tags to select or unselect skills to reflect your actual expertise.

Solid tumor understandingHematology cancer models vitro skillsCell cultureCell signaling bioassaysWestern blotCell death measurementFlow cytometryMulti-parameter flow data-vitro tumor modelsGenetic toolsCell line engineeringCell biology techniquesBiochemical techniquesCell signaling pathwaysMolecular biology skillsIntracellular signaling assessmentTranscriptomic data analysisData reportingDrug discoveryImmunoprecipitationImmunofluorescenceLuciferase activityMSDLuminexProblem solvingInterpersonal skillsCollaborationBiopharmaceutical IndustryAntibody Drug Conjugates

Required

BS with 3+ years or MS with 1+ year experience in Biology, Oncology, Biochemistry, Pharmacology, Immunology or a related field

Depth of understanding of solid tumor and hematology cancer models

Experience with a range of in vitro skills for the analysis of human tumor cell function (e.g. cell culture, cell signaling bioassays, Western blot, and cell death measurement in primary and cell line cultures)

Experience conducting flow cytometry and visualizing/quantitating high content multi-parameter flow data

Experience with multiple in-vitro tumor models (2D, 3D, organoid etc)

Experience with genetic tools for cell line engineering (si/shRNA, CRISPR, transfection, transduction)

Experience with cell biology and biochemical techniques to characterize cell signaling pathways (e.g. immunoprecipitation, immunofluorescence, luciferase activity, MSD/Luminex)

Molecular biology skills including assessment of intracellular signaling and, generating and/or analyzing transcriptomic data

Works equally well independently and in collaboration to execute assigned in a manner consistent with project goals. Reports data in a clear and concise manner, with a comprehensive understanding of its implications within the overall context of drug discovery.

Strong interpersonal and collaboration skills together with evidence of having used these to support problem solving and delivery in a collaborative environment.

Preferred

Prior experience in the biopharmaceutical industry preferable but not required.

Familiarity with antibody drug conjugates or other targeted delivery modalities

Familiarity with biology of tumor microenvironment (TME) and immunotherapy

Knowledge of the drug discovery process and publications in credible scientific journals

Company

AstraZeneca

Glassdoor

4.1

AstraZeneca is a pharmaceutical company that discovers, develops, manufactures, and markets prescription medicines. It is a sub-organization of Investor AB.

Founded in 1999

Cambridge, Cambridgeshire, GBR

10,001+ employees