31 applicants
GAP Solutions, Inc. · 2 days ago
Biologist (Mice/Malaria)
Bethesda, MD
Full-time
Onsite
Mid Level
4+ years exp
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Hiring Manager
Nehul Kapoor
Insider Connection @GAP Solutions, Inc.
Responsibilities
Manage the execution of •in vivo• rodent research within the Malaria Insectary Facility.
Perform a variety of procedures and techniques including (but not limited to) Plasmodium sporozoite dissection, in vitro functional assays, molecular cloning, PCR, cell culture, recombinant protein production, and multi-parameter flow cytometry.
Expand and maintain mosquito cultures according to established protocols.
Monitor the infection status of mosquitoes: blood feeding, natural transmission, and parasite isolations.
Maintain malaria infected mosquito colonies and conduct in vivo malaria challenge experiments in rodents.
Conduct pre-clinical evaluation (PK and PD experiments) for malaria vaccines and monoclonal antibodies in animal models.
Develop methods to evaluate the protective effect of vaccines and mAbs in malaria in vivo models (via bioluminescence, immune- and clinical pathology analysis.
Design rodent malaria layouts/challenges to establish new protocols, procedures, doses and risks for malaria experiments with the objective of providing data sets that support safe human testing.
Proficiently perform common and specialized •in vivo• technical procedures necessary to maintain the progress of in vivo malaria experiments.
Plan, execute, and arrange relevant experiments, techniques and procedures within appropriate quality standards and timelines.
Regularly participate in meetings that are conducted to define vaccine development, antibodies, and manuscript publications on the area of malaria.
Meticulously collect, analyze, interpret, and report data for presentations, reports, and publications from diverse malaria experiments.
Record all procedures and research project data, data analyses, and analytical conclusions of analyses in government-authorized notebooks and electronic systems in accordance with applicable regulations and procedures.
Monitor and maintain inventory of routine laboratory supplies to ensure maximum efficiency; make recommendations and prepare purchase requests as needed.
Perform routine maintenance of the lab work area and specialized instruments and equipment.
Qualification
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Required
Bachelor’s degree in a related field.
Minimum of four (4) years of related work experience.
Requires extensive experience with relevant laboratory practices, materials, and practice.
Must have hands on proficiency with common in vivo technical procedures in mice (compound administration, sample collection, imaging, surgery).
Must have basic skills in applicable computer programs.
Preferred
Preferred experience in the following techniques is highly desirable: preclinical malaria mouse challenge models, mosquito salivary gland/midgut dissection, IVIS •in vivo• imaging, multi- parameter flow cytometry, fluorescence microscopy, antibody/protein purification and characterization, ELISA, ELISPOT.
Must strictly adhere to safety standards and lab policies and maintain compliance with necessary training.
Must be able to work well both independently and with others on a team.
Must be able to maintain high level of organization, accuracy and attention to detail.
Must be able to make detailed observations, analyze data, and interpret results independently.
Must be able to apply creative problem-solving skills and sound judgment in making timely decisions.
Requires flexibility to handle multiple tasks and provide support for multiple projects in a fast-paced laboratory environment.
Ability to communicate effectively, orally and in writing, with non-technical and technical staff.
Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects
Company
GAP Solutions, Inc.
GAP Solutions champions the missions of our Federal Government customers and delivers value through people, process, and solutions.
501-1,000 employees
Funding
Current Stage
Late StageTotal Funding
unknown2017-12-06Acquired· by System One
Leadership Team
NICK GISMONDI
Executive Vice President & Chief Operating Officer
Recent News
2023-12-21
Company data provided by crunchbase
