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Arena BioWorks · 2 days ago
Director – Antibody Engineering
Cambridge, MA
Full-time
Hybrid
Director
8+ years exp
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Responsibilities
Lead optimization campaigns for new antibodies against novel targets.
Develop and optimize workflows to enhance antibody potency, selectivity, and format.
Oversee and innovate display-based approaches, in vitro biochemistry, and biophysics methods.
Collaborate with other teams to identify and validate novel therapeutic targets.
Generate and present data, lead discovery initiatives, and provide oversight to scientists and technicians.
Assume additional responsibilities as needed across the Protein Therapeutics Group.
Qualification
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Required
Ph.D. in Biochemistry, Bioengineering, Biophysics, Molecular Biology, or related field, with at least 8–10 years postgraduate experience in an academic or industry setting
Demonstrated leadership experience in the biochemical characterization of antibodies for potency, specificity, and stability optimization as well as antibody-antigen characterization techniques (e.g. epitope mapping)
Deep expertise in auxiliary technologies (FACS-based selections; next-generation sequencing; SPR/BLI and nanoDSF for protein characterization) is highly desirable
Expertise in alternative antibody formats, Fc-engineering, and/or antibody bioconjugation is critical as is the incorporation of key biochemistry and biophysics approaches into the antibody engineering workflow
Experience and willingness to integrate in silico methods (immuno-informatics, computational design, and emerging AI/ML methods) to accelerate protein engineering and antibody optimization at the benchtop
Highly adaptable, strong problem solver, with the ability to innovate and a passion for collaboration
Strong verbal and written communications skills
Highly organized and proficient in documentation, LIMS, and presentation of data
Ability to prioritize tasks, set deadlines, and adapt to shifting priorities in response to changing deadlines and needs of the lab
Possesses an eager, proactive and collaborative approach to each day; must be a self-starter and persistent in achieving objectives to support our scientific and business goals
Company
Arena BioWorks
Arena BioWorks is a biomedical research institute.
11-50 employees
Funding
Current Stage
Early StageCompany data provided by crunchbase
