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Company

Original Job Post

Sanofi · 2 days ago

Senior Scientist

Waltham, MA

Full-time

Onsite

Senior Level

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Health CareLife Science

H1B Sponsorship

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Responsibilities

Performing structure-based protein engineering and optimizing antigen display on various platforms using computational tools like Schrödinger, MOE, and Rosetta.

Designing novel antigens with conformational B cell epitopes, T cell epitopes, and minimal off-target immunogenicity.

Leading the investigation and development of next-generation methods for computational biology.

Performing cryo-EM sample preparation, data collection, and model building for viral and bacterial antigen/antibody complexes.

Networking internally and externally, participating in relevant project teams, and maintaining communication with various company areas.

Qualification

Find out how your skills align with this job's requirements. If anything seems off, you can easily click on the tags to select or unselect skills to reflect your actual expertise.

SchrödingerMOERosettaCryo-EM sample preparationGrid clippingCryo-EM machinesGlaciosKriosCryo-EM data collection softwareSerialEMEPUCryo-EM data processingCryoSPARCModel buildingCootPhenixIsoldePlanExecute scientific studiesTroubleshootingStructural viewing programPymolChimeraXViral fusion proteinAntibody biologyAlphafold 3Molecular Dynamics

Required

PhD in Computational Biology, Biophysics, Structural Biology, or closely-related discipline.

Experience with Schrödinger, MOE or Rosetta is required.

Experience with cryo-EM sample preparation and grid clipping is required.

Experience with cryo-EM machines (Glacios and Krios) and familiarity with cryo-EM data collection software (SerialEM and EPU) is required.

Experience with cryo-EM data processing (CryoSPARC) and model building (Coot and Phenix, Isolde) is required.

Ability to independently design, plan and execute scientific studies, including operation and maintenance of relevant instruments and troubleshooting are required.

Advanced skill in structural viewing program such as Pymol and ChimeraX is required.

Experience with viral fusion protein and antibody biology is required.

Preferred

Experience with Alphafold 3 and molecular dynamics is preferred.

Benefits

High-quality healthcare

Prevention and wellness programs

At least 14 weeks' gender-neutral parental leave

Company

Sanofi

Glassdoor

4.0

Sanofi is a healthcare company that provides treatments and the protection of life-saving vaccines.

Founded in 1973

Paris, Ile-de-France, FRA

10,001+ employees

https://www.sanofi.com

H1B Sponsorship

Sanofi has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Trends of Total Sponsorships

2023 (30)

2022 (95)

2021 (44)

2020 (45)