Takeda · 7 hours ago
Senior Staff Engineer, Modeling
Boston, MA
Full-time
Onsite
Senior Level, Lead/Staff
$137K/yr - $215K/yr
3+ years expTakeda is a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. The Senior Staff Engineer – Modeling will lead the design, development, optimization, and scale-up of manufacturing processes for synthetic molecule drug substances using process modeling and simulation principles.
BiotechnologyHealth CareManufacturingMedicalPharmaceutical
Responsibilities
Lead and contribute to the design, development, optimization, and scale-up of manufacturing processes for synthetic molecule drug substances using process modeling and simulation principles
Utilize advanced process modeling tools and digital twin functionalities, implementing model-based design of experiments for process characterization and risk assessment
Lead and develop experimental designs and workflows for model development, validation, and verification
Collaborates with cross-functional and external partners to develop and deploy digital twins of unit operations
Partner with Automation, Manufacturing, Process Engineers, and PAT experts to develop modeling and simulation (M&S) solutions that can be deployed across the global organization for in-silico process design, development, and optimization
Recommend, justify and implement in silico tools and an 'in-silico first' approach to process development
Contribute to the democratization of modeling and simulation tools & results within global SMPD
Develop project or significant technical strategy and leverages technical skill(s) as a resource/expert within the department
Recognized as a technical expert and resource within the function
Contribute significantly and independently to project work as well as the development of platforms, which may include multiple projects within functional area
Proactively analyze technical issues and coordinate potential resolutions with project team members based on model and simulation predictions
Review, interpret and communicate data cross functionally within pharmaceutical sciences and project teams
Significant technical responsibility for a project area/technical program within the department and potentially across Pharmaceutical sciences
Stay current in novel process modeling and simulation tools and platforms, identify process trends and defines/champions process strategy
Influence and support initiatives related to driving scientific and technical improvement within the function and potentially cross-functionally
Identify topics for initiatives and lead local/global initiatives on behalf of senior staff
Author relevant sections of regulatory documents, validation plans, reports and peer reviewed manuscripts
Identify vendors and build relationships to gain access to technologies as needed to deliver on pipeline and platform technology goals
Manage key vendor relationships across multiple projects as appropriate, and proactively affects resolution of issues arising at vendors
Represent Takeda and is an active member on pre-competitive collaborations with academic and industrial partners
Qualification
Required
Bachelor's degree in Chemical Engineering or a related pharmaceutical science with 11+ years of relevant industry experience
Master's degree in Chemical Engineering or a related pharmaceutical science with 9+ years of relevant industry experience
Ph.D. or postdoctoral fellowship in Chemical Engineering or a related pharmaceutical science with 3+ years of relevant industry experience
Strong knowledge and understanding of chemical reaction engineering and catalysis, with proven ability to demonstrate skills in these fields
Strong knowledge and understanding of transport phenomena and thermodynamics
Extended experience with commercially available reaction kinetic modeling software such as Ansys, ReactionLab, Dynochem, and gPROMS
Extended experience with commercially available software for computational fluid dynamics (CFD) modeling such as Ansys, Star CCM+, MStar CFD
Proficient in communicating and data collection from systems such as sensors, controllers, and industrial systems
Experience with Matlab, Python, R, SQL, and good coding practices
Preferred
Experience with common statistical methods, basic data science principles, and AI/ML methodologies
Hands-on experience in wet lab process development
Experience in multivariate analysis and Principal Component Analysis (PCA)
Understanding of synthetic molecule process development activities
Understanding of current Good Manufacturing Practices (cGMP)
Benefits
Short-term and/ or long-term incentives
Medical, dental, vision insurance
401(k) plan and company match
Short-term and long-term disability coverage
Basic life insurance
Tuition reimbursement program
Paid volunteer time off
Company holidays
Well-being benefits
Up to 80 hours of sick time
Up to 120 hours of paid vacation
Company
Takeda
Takeda is a biopharmaceutical company that researches and develops pharmaceutical drugs.
10001+ employees
H1B Sponsorship
Takeda has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (45)
2024 (39)
2023 (38)
2022 (34)
2021 (44)
2020 (18)
Funding
Current Stage
Public CompanyTotal Funding
$2.46B2025-06-27Post Ipo Debt· $2.4B
2016-09-01Grant· $19.8M
2016-05-08Grant· $38M
Leadership Team
Christophe Weber
President and CEO
Schuyler Fairfield
Senior Vice President, Global Head of Supply Chain
Recent News
2025-12-30
Company data provided by crunchbase