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Moderna · 16 hours ago

Director, Therapeutics Translational Research

Cambridge, MA

Full-time

Hybrid

Director/Executive

$167K/yr - $301K/yr

10+ years exp

Moderna is pioneering the development of mRNA-based cancer vaccines and therapeutics, and they are seeking a Director of Target Profiling to focus on forward translation to stratify and/or identify patients for early clinical trials. This role is critical in ensuring an efficient transition between preclinical research and clinical development, leading a research team to develop precision patient profiling methodologies and drive transformational drug development in oncology and autoimmune therapeutics.

BiotechnologyGeneticsHealth CareMedicalPharmaceuticalTherapeutics

Comp. & Benefits

No H1B

U.S. Citizen Only

Responsibilities

Develop and validate cutting-edge methodologies, including ctDNA, MRD, and protein-based assays, to monitor disease progression and therapeutic efficacy in a variety of clinical settings and disease indications

Lead the development of stage-appropriate CDx assays to enable precision patient profiling and inform strategies for therapeutic intervention

Manage the implementation of flow cytometry and other advanced profiling techniques to characterize and/or stratify patient populations effectively

Collaborate with Preclinical Program teams, Translational Medicine and Clinical Biomarker teams to define and implement comprehensive translational strategies to drive programs from concept to clinic

Stay at the forefront of scientific and technological advancements in precision targeting and companion diagnostics

Contribute to the broader translational research team strategy, fostering innovation and excellence

Oversee relationships with CROs and internal labs to ensure the timely completion of assay development, qualification, and validation studies, delivering high-quality data for translational research projects

Mentor and develop junior scientists within the translational research team, fostering a culture of scientific excellence and continuous learning

Act as a scientific liaison and thought partner for key internal and external collaborators, including development and regulatory colleagues, academic institutions, and industry collaborators in the oncology space

Contribute to the preparation of regulatory submissions, scientific publications, and presentations, effectively communicating translational research outcomes

Qualification

Ph.D. in relevant disciplineTranslational research experienceFlow cytometry expertiseCtDNA sequencingMRD methodologiesProtein-based assaysCompanion diagnosticsRegulatory submissions experienceCommunication skillsProject management skillsLeadership skillsInterpersonal skills

Required

Ph.D. in a relevant scientific discipline (e.g., oncology, immunology, cancer biology, immune-oncology) with a minimum of 10 years of experience in translational research within the pharmaceutical or biotechnology industry, preferably in immune-oncology or autoimmune therapeutic areas

Understanding of therapeutic development strategies

Strong background in developing flow cytometry, ctDNA sequencing, MRD methodologies, and protein-based assays to inform clinical development

Excellent communication and collaboration skills, with experience working in cross-functional teams

A results-driven mindset, capable of thriving in a fast-paced, innovative environment

A passion for advancing precision medicine to improve outcomes for patients

Demonstrated ability to innovate translational approaches for novel therapeutic concepts or modalities (ideally including experience with cell therapy and cancer vaccine platforms)

Experience with regulatory submissions and interactions with health authorities is highly desirable

Demonstrated success in developing and integrating companion diagnostics and disease monitoring tools into clinical development plans

Excellent project management and organizational skills, with the ability to manage multiple cancer vaccine projects simultaneously

Strong leadership and interpersonal skills, with the ability to influence and lead cross-functional teams

Demonstrated proficiency in effectively managing and developing direct reports

Exceptional communication skills, both written and verbal, with the ability to effectively convey complex scientific information related to cancer vaccines to a variety of audiences