Apply on Employer Site

Manifold Bio · 8 hours ago

Project Team Lead

Boston, MA

Full-time

Onsite

Senior Level

7+ years exp

Manifold Bio is a dynamic biotech company building a pipeline of targeted biologics using a novel in vivo-centric discovery approach. They are seeking an experienced drug discovery and development Project Team Leader to lead cross-functional scientific teams to progress novel tissue-targeted therapeutic programs from early discovery to early clinical evaluation.

BiotechnologyHealth CarePharmaceuticalTherapeutics

Responsibilities

Provides strategic and scientific leadership for cross-functional project teams focused on the development of tissue-targeted therapeutic molecules as they transition from early discovery (lead identification) into early clinical development

Develops clear work plan that maps out timing and resourcing requires to execute on critical path activities to progress novel lead tissue-targeted therapies from lead ID through early clinical testing, including candidate nomination, nonclinical PK and safety evaluation, CMC activities, regulatory submissions, and early clinical testing

Maintains team focus on efficient execution IND-enabling workplans. Works with project managers to track execution of critical path activities relative to target timelines and budget

Updates strategy based on emerging scientific data, changes in competitive landscape, and company strategic priorities; supports timely and clear project team decision-making that aligns with that strategy

Facilitates identification and resolution of issues/gaps; risks and risk-mitigation strategies. Prioritizes timely, resource-efficient solutions that are aligned with company priorities

Ensures cross-functional project team decisions are made in a timely manner and are aligned with company strategic priorities and latest scientific data

Advocates for the program with internal and external stakeholders; supports two-way communication between senior leadership and project team members. Ensures the opinions and perspectives of internal and external partners and stakeholders are heard and understood

Fosters a team culture of rigor, grit, accountability, and continuous improvement

Qualification

Drug development expertiseBiologic therapies experienceProject leadershipCRO/CDMO oversightCross-functional team managementCommunicationTime management

Required

A PhD degree in life sciences or a scientific discipline related to drug development; MD, PharmD or MS with strong scientific and drug development background also considered

At least 7 years of biotech/pharmaceutical industry experience in drug development, spanning from discovery through initiation of first-in-human clinical studies

Experience in discovery and development of biologic and / or oligonucleotide therapies, with a focus on neuroscience, motor, or cardiometabolic therapeutic areas preferred

Excellent knowledge of drug development processes and deliverables at each stage of the pipeline

Successful track record of leading projects/program teams in a cross-functional team environment from early discovery through IND-enabling activities and ideally through early clinical development

Experience successfully leading projects with participation by external collaborators

Experience in oversight and successful integration of CROs, CDMOs, contractors and consultants

Excellent leadership skills with exceptional decision-making and analytical skills

Outstanding written and oral communication skills, with proven ability to build and maintain positive, collaborative working relationships

Excellent time management skills; comfortable driving toward on-time execution of deliverables in context of uncertain drug-development environment

Preferred

Experience in discovery and development of biologic and / or oligonucleotide therapies, with a focus on neuroscience, motor, or cardiometabolic therapeutic areas