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Glyphic Biotechnologies · 5 months ago

Senior/Staff Scientist, Biopolymer Chemistry

Berkeley, CA

Full-time

Onsite

Senior Level

$120K/yr - $183K/yr

5+ years exp

Glyphic Biotechnologies is focused on revolutionizing protein science through their innovative proteome sequencing platform. They are seeking a highly motivated Scientist with expertise in biopolymer chemistry to contribute to the development of this cutting-edge technology, working collaboratively with a cross-disciplinary team.

BiotechnologyHealth CareLife Science

Responsibilities

Design, develop, and optimize high throughput chemical reagent evaluation for single molecule protein sequencing, ensuring high sensitivity, specificity, and reproducibility

Synthesize assay specific reagents and materials for the proteome sequencing platform

Develop and/or validate peptide sample preparation schemes, such as C-terminal conjugation and amino acid sidechain derivatization

Collaborate with cross-functional teams to problem solve and integrate novel solutions into the assay workflow

Analyze complex experimental data, generate detailed reports, and provide actionable insights to guide further development

Utilize statistical methods and data visualization tools to interpret assay performance and ensure rigorous quality control

Prepare and maintain comprehensive documentation of experimental protocols, standard operating procedures (SOPs), and results

Drive innovation in reagent and compound synthesis and design and contribute to intellectual property development

Qualification

Bioconjugation methodsPeptide synthesisNucleic acid synthesisAnalytical instrumentationProtein purificationData analysis softwareStatistical softwareProblem-solving skillsCommunication skillsAttention to detail

Required

PhD in chemistry, organic chemistry, or related field with 5+ years of relevant post-graduate experience, preferably in an industrial or startup setting

Comprehensive knowledge in bioconjugation and biorthogonal conjugation methods and techniques

Proficiency in site specific amino acid chemistry (C-terminal, amino acid sidechains beyond C & K)

Experience with peptide synthesis, characterization, and purification

Experience with nucleic acid synthesis, natural and modified analogs

Knowledgeable about protein purification and fractionation from complex sample matrices

Analytical experience with HPLC, LC/MS, NMR, FTIR, UV/VIS, CE

Proficiency in scalable surface chemistry methods and techniques for flow cells and/or solid supports

Excellent problem-solving skills and attention to detail

Strong written and verbal communication skills, with the ability to document experiments clearly and collaborate effectively with multidisciplinary teams

Experience in data analysis software

Experience in statistical and DOE software

Adapts to fast-paced environments with changing priorities and responsibilities