Generate:Biomedicines · 4 days ago
Head of CryoEM, Executive Director
Andover, MA
Full-time
Onsite
Director/Executive
$235K/yr - $353K/yr
10+ years expGenerate:Biomedicines is a pioneering therapeutics company at the intersection of machine learning, biological engineering, and medicine. They are seeking a visionary leader to head their CryoEM group, overseeing a high-throughput structural biology platform essential for drug generation across modalities.
Artificial Intelligence (AI)BiotechnologyHealth CareMedicalProduct Research
Responsibilities
Lead a world-class team of cryo-EM scientists and engineers
Develop and execute a strategic roadmap for a high-throughput cryo-EM facility in close collaboration with Generate’s Machine Learning, Protein Science, and Informatics teams, aligned with Generate’s scientific priorities and platform vision
Serve as a cross-functional integrator across wet-lab operations, computational technology development, and platform engineering
Serve as a key thought partner to senior leadership on infrastructure investments and innovation, capability development, and talent strategy
Identify, establish, and manage external collaborations and partnerships to expand and enhance internal capabilities
Oversee the full experimental cryo-EM pipeline, including construct design, sample preparation, image acquisition, data collection, reconstruction and 3D structure resolution
Champion innovation by implementing creative strategies to boost speed, data quality, and overall pipeline efficiency
Drive continuous improvement across key metrics such as throughput, microscope uptime, success rates, and quality metrics
Guide development of custom algorithms, workflows, and experimental technologies, in collaboration with internal ML, software, and experimental/engineering teams
Ensure that cryo-EM workflows and data outputs meet quality standards suitable for regulatory submission and downstream therapeutic development
Manage and mentor a multidisciplinary team, fostering a culture of curiosity, scientific rigor, and collaboration
Create an inclusive environment that supports skill development, team cohesion, and career growth
Qualification
Required
PhD in structural biology, biochemistry, biophysics, bioengineering, or a related field
10+ years of hands-on experience with cryo-EM in both academic and industrial settings, with a strong record of publication and/or platform development
Strong familiarity with the computational and algorithmic aspects of cryo-EM data processing and integration with ML workflows
Experience collaborating with ML teams on joint algorithm and hardware-software interface development
Strong understanding of protein design, expression, and purification workflows
Excellent communication and interpersonal skills, with a demonstrated ability to influence across disciplines
Demonstrated success in leading and scaling scientific or technical teams (minimum 3+ years in a leadership or management capacity)
Passion for using cutting-edge tools and technology to redefine the practice of structural biology
Benefits
Annual bonus
Equity compensation
Competitive benefits package
Company
Generate:Biomedicines
Pioneering generative biology to create breakthrough therapeutics.
201-500 employees
H1B Sponsorship
Generate:Biomedicines has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (7)
2024 (12)
2023 (9)
2022 (3)
2021 (2)
2020 (1)
Funding
Current Stage
Growth StageTotal Funding
$693MKey Investors
Samsung Life Science FundAlumni VenturesFlagship Pioneering
2024-12-18Series Unknown
2023-09-14Series C· $273M
2021-11-18Series B· $370M
Leadership Team
Gevorg Grigoryan
Founding CTO
Recent News
FierceBiotech
2025-10-28
Company data provided by crunchbase