Spear Bio · 5 months ago
Scientist/Senior Scientist, Assay Development
Woburn Office
Full-time
Onsite
Mid, Senior Level
1+ years expSpear Bio is a rapidly growing start-up dedicated to revolutionizing early disease diagnosis and monitoring through their innovative immunoassay platform. The Scientist/Senior Scientist in Assay Development will be responsible for advancing the development of ultrasensitive immunoassays, collaborating with cross-functional teams, and mentoring junior scientists.
BiotechnologyHealth CareHealth Diagnostics
Responsibilities
Develop a portfolio of ultrasensitive immunoassays throughout the product lifecycle from screening and optimization, to feasibility and verification; this includes planning, design and execution of benchwork involving antibody selection, conjugation of reagents, buffer optimization, and assay validation of sample matrices for research and clinical use
Conduct scientific research on design and troubleshooting to achieve assay specifications including dynamic range, limit of detection, spike and recovery, precision, accuracy, and assay linearity; employ DOE and data analysis methodologies to meet project timelines
Organize, document, and review reports for assay development process in preparation for product launch
Contribute to scientific literature and conferences, internal reports, documents and communication including the writing or creation of abstracts, peer-reviewed journal articles, poster presentations, and marketing materials
Collaborate with cross-functional teams to generate marketing materials, internal reports, conference posters, and presentations utilizing immunoassay development data results
Mentor junior scientists and provide guidance on projects
Qualification
Required
Ph.D. (+ 1-3 years) or MS (+ 3-7 years) of direct life sciences industry experience specializing in ultrasensitive, blood-based immunoassay design, development, and troubleshooting for neurodegenerative biomarkers. This experience is required for consideration
Strong, hands-on expertise utilizing ultrasensitive platforms like Simoa, MSD, Lumipulse, and/or homebrew platforms for novel immunoassay development
Deep subject matter expertise in ultrasensitive immunoassay development includes: assay planning, optimization, and troubleshooting with specific focus on antibody screening and conjugation, preanalytical serum, plasma or EV sample preparation and evaluation, assay diluent formulation, and homogenization for multiplexing. This experience is required for application consideration
Demonstrated experience utilizing literature to remain at the forefront of research for neurodegenerative protein biomarkers and diseases, and applying the latest research insights to generate immunoassays for clinical application
Experience with FDA and CLSI guidelines to design and execute feasibility and verification testing for developed assays
Benefits
Competitive compensation
Meaningful stock ownership
Comprehensive benefits
Great work environment
Company
Spear Bio
Spear Bio is a biotech company that focuses on the detection of ultrasensitive protein.
11-50 employees
H1B Sponsorship
Spear Bio has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2024 (2)
2023 (3)
2022 (2)
2021 (1)
Funding
Current Stage
Early StageTotal Funding
$45M2024-07-29Series A· $45M
2023-11-13Seed
Leadership Team
Feng Xuan
Co-Founder & CEO
Recent News
Company data provided by crunchbase