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Pattern Biosciences · 5 months ago

Scientist, In Vitro Models

South San Francisco

Full-time

Onsite

Senior Level

Pattern Biosciences is a company focused on designing biological circuits for targeted cancer therapy. They are seeking a scientist to design, build, and validate in vitro human models that support their preclinical development pipeline, including optimizing multi-omics workflows for profiling disease models.

BiotechnologyGeneticsHealth CareTherapeutics

Responsibilities

Develop advanced in vitro human models of healthy and diseased primary cells, tissues, and organs to serve as a translationally relevant testing and validation platform

Scale up culture of in vitro models to support high-throughput testing workflows

Design assays for model characterization and to establish translational relevance

Collaborate with our Synthetic Biology and Computational Biology teams to develop workflows for comprehensive high-throughput testing of multiple synthetic genetic components, their combinations, and therapeutic candidates

Implement multi-modal bulk and single-cell assays as an integral part of testing workflows

Optimize and establish standard operating procedures for patient-derived tissue processing and dissociation

Plan and manage complex projects including interfacing with clinical partners for sample acquisition and sequencing service providers

Liaise with CROs, plan and oversee technology transfer and study execution at contract organizations, as needed

Maintain detailed, well-organized documentation of experiments and data

Qualification

Vitro model developmentSingle-cell genomicsBulk genomicsTissue engineering3D bioprintingBioreactorsMicrofluidicsProject managementCollaborationDocumentation

Required

PhD in molecular biology, genomics, bioengineering, immunology or a related field

Excellent knowledge of ex vivo/in vitro models, ideally in oncology (tumor organoids, tumor explants), as well as healthy/primary human and animal cells (primary cells, stem cell models, spheroids, organoids, organotypic culture, organs-on-chip)

Proven track record of building complex model systems including co-culture systems, 3D cellular models, or organoids

Experience with primary tissue handling and processing

High motivation with a strong work ethic and dedication to generating impact

Ability to go from idea to data to conclusions in an independent manner

Hands-on experience with tissue engineering, biomaterials, 3D bioprinting, bioreactors, or microfluidics

Hands-on experience performing single cell and bulk genomics experiments including sample preparation, library preparation, and sequencing