Genmab · 1 week ago
Senior Scientist/Associate Director - Clinical Pharmacology & Quantitative Science
Princeton, NJ
Contract
Hybrid
Senior Level, Lead/Staff, Director/Executive
$123K/yr - $185K/yr
2+ years expGenmab is an international biotechnology company dedicated to improving the lives of patients through innovative antibody therapeutics. The role of Quantitative Systems Pharmacology (QSP) Modeler involves leading QSP strategies for drug products, developing and implementing models to support the development of novel therapies, and collaborating with various teams to enhance drug development efficiency.
BiotechnologyHealth CareManufacturingMedical
Responsibilities
Serve as the QSP lead on a number of pre-clinical and clinical development programs
Oversee all aspects of QSP strategies for candidate drug products from early development through late stage development using model-based approaches to improve the efficiency of drug development
Develop and implement QSP models, supporting the development of novel therapies including antibody-drug conjugates (ADC), bispecific antibodies, immuno-oncology agents, and other mechanisms
Collaborate with discovery, preclinical, translational and clinical development as well as other scientists in the Translational and Quantitative Sciences group to develop mathematical models and help understand targeted biological pathways and interactions of novel therapeutic modalities
Frame critical questions to establish the right modeling & simulation strategies that enable lead optimization, identify PK/PD relationships, inform dose selection and Go/No Go decisions by utilizing mechanistic QSP models
Design and build models based on preclinical and emerging clinical data as well as leveraging literature sources of data and relevant immuno-oncology and oncology knowledge
Cultivate data in support of model construction and interpretation, define key issues, and provide simulations of disease, mechanism of action, and (non)clinical studies
Contribute to best practices on application of QSP and other mathematical or statistical analyses (e.g. artificial intelligence, machine learning, deep learning) across the clinical pharmacology group
Qualification
Required
Ph.D/Pharm.D/M.D with training in chemical or biomedical engineering, immunology, pharmaceutical sciences, mathematics, statistics, or equivalent area with 2-5 years of industry and/or academic experience in mathematical modeling of biological systems
Strong competency in applying modeling and simulation related software such as Matlab/SimBiology, Julia, or other domain-specific languages is required
Proficiency with systems modeling approaches such as ordinary, partial, and/or stochastic differential equations, boolean, agent-based, or other advanced mechanistic modeling approaches is essential
Understanding of PK/PD analysis and translational modeling of preclinical PK/PD data, and mechanism-based PK/PD systems using preclinical and/or clinical data with biologics therapeutics is also required
Demonstrated ability and experience in applying modeling and simulation approaches to enable rational and efficient preclinical and clinical drug development are required
Demonstrated ability to present results at cross-functional teams, department meetings, review committees, and conferences
Flexible, with positive attitude, ability to work with multidisciplinary teams, prioritize projects effectively and communicate at all levels within the company
Excellent written, verbal and interpersonal communication skills
Domestic and international travel will be required
Preferred
Extensive experience and strong understanding of oncology drug development is preferred
Experience in Machine Learning/Artificial Intelligence is preferred
Benefits
401(k) Plan: 100% match on the first 6% of contributions
Health Benefits: Two medical plan options (including HDHP with HSA), dental, and vision insurance
Voluntary Plans: Critical illness, accident, and hospital indemnity insurance
Time Off: Paid vacation, sick leave, holidays, and 12 weeks of discretionary paid parental leave
Support Resources: Access to child and adult backup care, family support programs, financial wellness tools, and emotional well-being support
Additional Perks: Commuter benefits, tuition reimbursement, and a Lifestyle Spending Account for wellness and personal expenses
Company
Genmab
Genmab is a biotechnology company focused on developing fully human antibody therapeutics for the potential treatment of cancer.
1001-5000 employees
H1B Sponsorship
Genmab has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (14)
2024 (10)
2023 (6)
2022 (3)
2021 (3)
2020 (1)
Funding
Current Stage
Public CompanyTotal Funding
$11.7BKey Investors
Morgan Stanley Senior FundingGlaxoSmithKlineIndex Ventures
2025-11-18Post Ipo Debt· $6B
2025-09-29Post Ipo Debt· $5.5B
2010-07-01Post Ipo Equity· $134M
Leadership Team
Anthony Pagano
Chief Financial Officer
Anthony Mancini
EVP & Chief Operating Officer
Recent News
2026-01-08
Company data provided by crunchbase