Tenvie Therapeutics · 4 months ago
Senior Scientist/Principal Scientist, DMPK
South San Francisco, CA
Full-time
Onsite
Senior Level
$160K/yr - $200K/yr
5+ years expTenvie Therapeutics is a biotechnology company focused on engineering small molecules for neurological diseases. They are seeking a highly motivated DMPK Scientist to contribute to small molecule drug discovery and development, guiding strategies and ensuring data-driven decision-making throughout the lifecycle of therapeutics.
BiotechnologyMedicalNeuroscienceTherapeutics
Responsibilities
Be a key contributor and subject matter expert to DMPK strategy applied to small molecule drug discovery through development by acting on interdisciplinary project teams
Manage and oversee external vendors for completing in vitro and in vivo studies
Contribute to the design and conduct of preclinical in vivo studies, and interpretation of data by building and implementing PK and PK/PD modeling and simulation and sensitivity analysis
Establish close partnerships with biology, pharmacology, toxicology, biomarker, and clinical for providing human dose predictions and therapeutic index
Oversee transfer of modeling strategies from preclinical space to implementation in clinical development
Effectively communicate DMPK data and its interpretation for decision-making to project teams
Serve as a subject matter expert to write Nonclinical Pharmacology sections of regulatory (IND/CTA) filings, IB updates, and responses to regulatory queries
Qualification
Required
MS or PhD in Drug Metabolism, Pharmacokinetics, Chemistry, or related scientific discipline with a minimum 5+ years of pharmaceutical drug discovery and development experience or BSc with 10+ years of experience
Excellent critical thinking and scientific skills with proven scientific expertise in small molecule metabolism and pharmacokinetics
Demonstrated success working effectively and collaboratively on cross-functional projects teams
Excellent oral presentation and written communication skills
Company
Tenvie Therapeutics
Tenvie Therapeutics is a biotechnology company that transforms the treatment of neurological diseases through engineered small molecules.
11-50 employees
Funding
Current Stage
Early StageTotal Funding
$200M2025-01-08Series A· $200M
Leadership Team
Tony Estrada
Co-Founder, President & CEO
Javier Vicente
VP, Research Operations
Company data provided by crunchbase