Apply on Employer Site

ProBio · 1 week ago

(Sr). Scientist, Upstream Process Development

Pennington, NJ

Full-time

Onsite

Mid, Senior Level

$80K/yr - $110K/yr

3+ years exp

GenScript Biotech Corporation is a global biotechnology group committed to making humans and nature healthier through biotechnology. ProBio, a part of GenScript, is seeking a Senior Scientist to support and lead the translation of research processes to GMP-compliant manufacturing, focusing on viral vector processes in a fast-paced biotechnology environment.

BiopharmaBiotechnologyLife ScienceMedicalPharmaceutical

H1B Sponsor Likely

Responsibilities

Conduct hands-on experimental work in the development of upstream unit operations (cell culture, transfection, and harvest/clarification) for viral vector (AAV, LVV) manufacturing process

Design, execute, and analyze cell culture experiments using Design of Experiments (DOE) principles and report data summary packages

Collaborate with internal/external partnerships to evaluate and implement new bioprocessing technologies and strategies

Develop and optimize process parameters to improve yield, quality, and consistency of viral vector production with guidance

Independently follow detailed and comprehensive project timelines

Support/drive the start up of AAV/LVV lab operations including, but not limited to: Draft, review, and approval of Standard Operating Procedures (SOPs), Implementation of Lean 6 sigma/5s best practices, and streamlining material flow

Present updates to project or cross functional teams on process development and manufacturing support activities

Read and understand scientific literature in gene and cell therapy, use the knowledge to generate ideas and contribute to process design and development

Perform other duties as assigned based on business needs

Qualification

Viral vector productionCGMP manufacturingProcess scale-upAnalytical methodsProject managementInterpersonal skillsProblem-solving skillsCommunication skills

Required

Conduct hands-on experimental work in the development of upstream unit operations (cell culture, transfection, and harvest/clarification) for viral vector (AAV, LVV) manufacturing process

Design, execute, and analyze cell culture experiments using Design of Experiments (DOE) principles and report data summary packages

Collaborate with internal/external partnerships to evaluate and implement new bioprocessing technologies and strategies

Develop and optimize process parameters to improve yield, quality, and consistency of viral vector production with guidance

Independently follow detailed and comprehensive project timelines

Present updates to project or cross functional teams on process development and manufacturing support activities

Read and understand scientific literature in gene and cell therapy, use the knowledge to generate ideas and contribute to process design and development

Perform other duties as assigned based on business needs

Bachelor's degree with 5-7 years, or Master's Degree with 3-7 years, or Ph.D. degree with 0-3 years' experience in Biology, Biochemistry, Chemical Engineering or equivalent with particular experience in gene and cell therapy product design

Experience with AAV and/or lentiviral vector production systems

Strong understanding of process scale-up, cGMP manufacturing technology transfer, and manufacturing support

Prior experience with cGMP manufacturing environment

Familiarization with analytical methods for viral vector characterization (qPCR, ELISA, HPLC)

Familiarization of regulatory requirements for gene therapy products (FDA, EMA)

Excellent organizational and project management abilities

Strong analytical and problem-solving skills with attention to detail

Strong interpersonal, verbal, and written communication skills

Company

ProBio

ProBio is a global contract development and manufacturing (CDMO) organization, which aims to accelerate the manufacturing of life-changing drugs, discover novel therapeutic targets, and develop innovative therapeutic approaches to manufacture best-in-class DNA, RNA, and protein-based therapeutics.

Founded in 2002

Pennington, New Jersey, USA

201-500 employees

https://probiocdmo.com/

H1B Sponsorship

ProBio has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (5)

2024 (8)