Humanwell Pharmaceutical US, Inc. ยท 4 months ago
Principal / Senior Principal Biologist or Pharmacologist in Drug Discovery
Ballwin, MO
Full-time
Onsite
Senior Level, Lead/Staff
10+ years expHumanwell Pharmaceutical US, Inc. is a pharmaceutical research and development laboratory focused on discovering novel therapeutics for pain and CNS diseases. They are seeking a Principal or Senior Principal Biologist/Pharmacologist to lead drug discovery programs, integrating in vitro and in vivo approaches to advance their pipeline.
Health CareMedicalPharmaceutical
Responsibilities
Provide strategic leadership in biology and pharmacology across pain and CNS drug discovery programs
Identify and validate novel targets, and design assays related to functional signal transduction pathways relevant to CNS and pain
Design, conduct, and oversee in vitro and in vivo efficacy, PK/PD, and mechanistic studies in relevant CNS disease models (e.g., pain, neurodegeneration, psychiatric disorders)
Develop, refine, and validate translational models to enhance predictive value in preclinical studies
Integrate pharmacology/biology findings with medicinal chemistry, DMPK, biomarkers, toxicology, and clinical input to drive candidate progression
Collaborate closely with regulatory teams to prepare IND submission packages and support regulatory interactions
Work with medical professionals to contribute to clinical trial protocol development
Manage CROs, external collaborations, and internal laboratory operations to ensure high-quality, reproducible science
Mentor and supervise junior scientists to build a strong and sustainable research team
Present strategy, progress, and results to project leadership, senior management, and external partners
Qualification
Required
Ph.D. (or equivalent degree) in Biology, Cell Biology, Pharmacology, Neuroscience, Physiology, or a related biomedical discipline
10+ years of industrial experience in pharmaceutical/biotech R&D, with significant depth in CNS or pain drug discovery
Demonstrated expertise in vitro assay development and/or in vivo CNS pharmacology (behavioral assays, imaging, surgical models, transgenic platforms)
Proven success in advancing molecules into IND-enabling studies
Strong knowledge of PK/PD principles, biomarker development, and translational pharmacology
Experience managing cross-functional teams, CROs, and external collaborators
Ability to work independently and collaboratively in a fast-paced, dynamic environment
Familiarity with regulatory guidelines for preclinical and clinical research
Excellent communication skills; ability to communicate in both English and Chinese is preferred
Preferred
Familiarity with modern CNS technologies and translation platforms
Track record of patents, publications, and/or clinical candidate nominations
Experience contributing to regulatory packages and IND submissions
Exposure across multiple therapeutic areas, with primary focus in CNS
Medical education or teaching experience is a plus
Benefits
Health insurance
401K
Vacation plan
Company
Humanwell Pharmaceutical US, Inc.
Humanwell Pharmaceutical US, Inc.
11-50 employees
H1B Sponsorship
Humanwell Pharmaceutical US, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (2)
2023 (2)
2022 (2)
2021 (2)
2020 (2)
Funding
Current Stage
Early StageRecent News
2025-05-17
Google Patent
2025-05-17
2025-02-18
Company data provided by crunchbase