Poseida Therapeutics, Inc. · 4 months ago
Scientist 3 – Immunology & CAR-T Cell Therapy
Towne Centre
Full-time
Onsite
Mid Level
$88K/yr - $164K/yr
3+ years expPoseida Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on advancing differentiated allogeneic cell therapies and genetic medicines. They are seeking a highly motivated Scientist 3 with expertise in immunology and CAR-T cell therapy to lead research efforts, including screening novel CAR constructs and executing functional assays for preclinical validation.
BiopharmaBiotechnologyGeneticsTherapeutics
Responsibilities
Advance platform development for a CAR-T cell therapy program from concept through preclinical validation
Design, execute, and analyze in vitro functional assays (e.g., T cell activation, cytokine secretion, antigen-specific suppression/expansion) to evaluate CAR-T activity and specificity
Screen and optimize CAR constructs for efficacy, antigen specificity, safety, and persistence, using flow cytometry, cytokine profiling, and molecular assays
Design and oversee in vivo studies in murine oncology and autoimmune models, including disease induction, CAR-T delivery, monitoring pharmacodynamics, and assessing therapeutic outcomes (clinical scores, histopathology, immunophenotyping)
Contribute to the strategic direction of the CAR-T platform, identifying key readouts and establishing preclinical assays to enable rapid iteration and data-driven decision-making
Collaborate cross-functionally with vector engineering, non-viral delivery, and translational teams to align CAR design and delivery approaches with program goals
Analyze and interpret complex datasets, prepare clear reports, and present findings in internal program meetings, cross-functional reviews, and governance updates
Contribute to external publications, conference abstracts, and patent filings relevant to CAR-T development for autoimmune indications
Maintain accurate and detailed experimental records in compliance with company standards and ensure high data integrity
Qualification
Required
Ph.D. in Immunology, Cell Biology, or related field with a minimum of 3 years (strong preference for 5 to 7 years) of relevant postdoctoral or industry experience
Strong background in autoimmunity is a plus
Proven expertise in CAR-T cell biology, T cell functional assays, and immune cell profiling
Experience with LNP delivery systems and non-viral gene transfer is highly desirable
Familiarity with relevant mouse models used in immune-oncology research (syngeneic models, patient-derived xenograft in humanized mice) is highly desirable
Strong data analysis skills and familiarity with software such as FlowJo, GraphPad Prism, and statistical tools
Excellent communication, organizational, and leadership skills
Benefits
Excellent career development opportunities
Highly competitive compensation
Comprehensive benefits
Company
Poseida Therapeutics, Inc.
Poseida was acquired by Roche in early 2025 and is now part of the Roche Group.
201-500 employees
H1B Sponsorship
Poseida Therapeutics, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (6)
2024 (7)
2023 (4)
2022 (2)
2021 (3)
2020 (1)
Funding
Current Stage
Public CompanyTotal Funding
$460.45MKey Investors
Astellas PharmaFidelityNovartis
2024-11-26Acquired
2023-08-07Post Ipo Equity· $50M
2022-08-04Post Ipo Equity· $70M
Leadership Team
Mark Gergen
Chairman and Chief Executive Officer
Johanna Mylet
Chief Financial Officer
Recent News
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