TCG Labs Soleil · 3 months ago
Principal Scientist, Protein Sciences, Analytical Characterizations
Corporate Headquarters (South San Francisco)
Full-time
Onsite
Senior Level, Lead/Staff
$140K/yr - $250K/yr
10+ years expTCG Labs-Soleil is a biotech company focused on translating scientific insights into therapeutic solutions. They are seeking a highly experienced Principal Scientist to lead analytical efforts within their Protein Sciences group, focusing on the development and characterization of biologics for pre-clinical therapeutic pipelines.
Biotechnology
Responsibilities
Design, develop, and implement analytical methods for the characterization of diverse biologics with an emphasis on LC-MS and biophysical characterization to drive discovery programs through the research pipeline
Establish and validate robust biophysical assays to characterize therapeutic biologics (monoclonal antibodies, bispecific antibodies, fusion proteins, etc.)
Design and execute experiments, make detailed observations, analyze and interpret data, and deliver results in a concise and timely manner to the team
Manage CROs and external collaborations on analytical development
Prepare precise technical summaries, protocols, and maintain appropriate documentation
Deliver concise data summaries to leadership and ensure clear communication with the development team
Lead program analytics efforts to support program progression
This is a full-time and lab-based position
Qualification
Required
Ph.D. (or equivalent) in biochemistry, biophysics, analytical chemistry, or a related field, offering 10+ years of monoclonal and multispecific antibody characterization experience in biotech or startup environments
Demonstrated leadership managing scientific teams and mentoring direct reports to drive performance and growth
Deep technical expertise in biophysical methods, including HPLC, CE, SPR, DSF, DSC, SEC-MALS, and LC-MS
Strong foundation in protein analytics, with extensive hands-on PTM characterization of biologic therapeutics
Proven track record in developability studies across monoclonal & multispecific antibodies, fusion proteins, and antibody-drug conjugates (ADCs)
Comprehensive understanding of biologics drug discovery—from hit-to-lead through lead optimization to candidate selection stages
Research-driven mindset with a clear orientation toward translating findings to deliver therapeutic solutions
Meticulous in data organization, adept at managing multiple projects simultaneously while maintaining high standards of quality
Exceptional written and oral communication skills for clear presentation of complex scientific data
Flexible team collaborator, rapidly adapting to new scientific domains and mastering new techniques
Proven ability to thrive and achieve results in fast-paced, dynamic, multitasking environments
Preferred
Experienced in CMC development processes and contributing to IND filing initiatives (highly desirable)
Benefits
Medical, Dental, and Vision Insurance
Life Insurance
Short and Long Term Disability
Health Savings Account (HSA)
Flexible Spending Accounts (FSA)
401k plan
PTO
Company
TCG Labs Soleil
At TCG Labs Soleil, we are establishing a pioneering venture-biotech model in collaboration with The Column Group.
11-50 employees
Funding
Current Stage
Early StageLeadership Team
Jin-Long Chen
Managing Partner, TCG Labs | Co-Founder and Chief Executive Officer, Soleil
Harding Luan
VP, Discovery Research and Co-Founder
Recent News
2025-07-26
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