UC Irvine ยท 5 months ago
Postdoctoral Scholar - Computational Biology
Irvine, CA
Full-time
Onsite
New Grad, Entry Level
$67K/yr - $80K/yrThe University of California, Irvine is offering a postdoctoral position under Dr. Stanley Ng to explore the relationship between multiple molecular layers in various tissues. The successful candidate will analyze data modalities and perform machine learning analyses to understand disease progression and treatment resistance.
Higher Education
Responsibilities
Explore the relationship between multiple molecular layers from epigenome to phenome at clonal resolution in various tissues
Analyze multiple data modalities from human and mouse tissues, including spatially-resolved somatic DNA mutations, gene and protein expression, and cryogenic electron tomography (cryoET) images
Perform bioinformatic integration of distinct data types and subsequent statistical and machine learning analyses to elucidate how alterations to various molecular layers in individual clones can lead to their respective contributions to disease development/progression, malignant transformation, and treatment-specific resistance
Develop computer vision based deep learning models to identify abnormal biomolecular structures in diseased cells at nanoscale resolution
Facilitate the identification of novel risk markers and therapeutic targets that will be validated in independent biological specimens and datasets
Qualification
Required
A PhD or MD/PhD degree with a focus on Epigenetics, Genetics, Genomics, Biology, Bioinformatics, Machine Learning, or a related field
Extensive experience in a research environment and at least 1 first-author publication in a reputable scientific journal
Proficiency in R, Python, and/or other programming languages, and familiarity with working in a Linux-based high-performance computing environment
Ability to work independently to drive projects forward
Ability to communicate effectively and collaborate as part of a multidisciplinary team
Ability to compose and deliver comprehensive presentations at scientific meetings and prepare research articles for peer-reviewed publications
A doctoral degree (e.g., Ph.D., M.D.) or the foreign equivalent is required. The applicant can either have their PhD at the time of the application, or could be working towards the PhD
Preferred
Expertise in statistical model development and the analysis of high-dimensional data, including next generation sequencing datasets
Experience with sectioning, fixing, and staining tissues for histology imaging, laser capture microdissection, and sample prep for (single-cell) sequencing
Expertise with ATAC-Seq, methylation profiling, genome/exome/targeted sequencing, mutation calling, single-cell analysis, RNA-Seq, proteomics, spatial technologies from 10X, NanoString or similar, cryoET or cryoEM analysis
Expertise in machine learning and mathematical/statistical inference (e.g., image classification/segmentation using deep neural networks, reinforcement learning, regularized regression and classification models, clustering, optimization)
Experience in developing computational analysis pipelines
Expertise with multi-core/multi-threaded parallelization using GPU-based hardware acceleration or similar
Experience with building highly distributable software (e.g., R packages, Python modules, Linux-based command-line tools, C programs, MATLAB applications, GitHub)
Company
UC Irvine
UC Irvine
Founded in 1965
10001+ employees
H1B Sponsorship
UC Irvine has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
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2025 (113)
2024 (86)
2023 (99)
2022 (76)
2021 (81)
2020 (79)
Funding
Current Stage
Late StageLeadership Team
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CEO Roundtable Member
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