BillionToOne · 9 hours ago
Clinical Genomics Scientist, Oncology
United States
Full-time
Remote
Entry, Mid Level
$158K/yr - $180K/yr
2+ years expBillionToOne is a next-generation molecular diagnostics company focused on transforming healthcare through innovative diagnostic solutions. They are seeking a Clinical Genomics Scientist in Oncology to drive somatic mutation variant interpretation and reporting, contributing to the development of clinical reporting policies and collaborating with various teams to enhance patient care.
BiotechnologyGeneticsHealth DiagnosticsMedical
Responsibilities
Somatic variant interpretation and data review: Perform somatic-based variant interpretation, diving into the literature and databases to classify variants and match treatments for reporting, performing verification as required with BAM file analysis
Clinical report drafting: Carefully draft reports for each requisition primarily using in-house reporting API, working closely with the engineering and QA teams on reporting, and the laboratory directors on report language
Somatic mutation interpretation and reporting policy development: Work closely with lab directors, R&D, medical, and other related functions to develop and modify the somatic interpretation SOPs in accordance with ACMG/AMP guidelines, and the latest published literature
Content curation: Contribute to curation of gene-level content such as domain and critical residue curation.Molecular tumor board: Serve as a subject matter expert in consulting with the medical science liaison team, and presenting in molecular tumor boards to facilitate knowledge sharing
Contribute to oncology R&D: Work closely with the R&D team to help with somatic oncology based projects, providing expertise on variant interpretation, biological pathways/mechanisms, and other gene/variant-level reviews and analyses
Qualification
Required
Ph.D. in Human Genetics, M.S. in Genetic Counseling, or related field
2+ years of experience in somatic variant interpretation based on ACMG/AMP guidelines in a clinical setting (alternatively, 1+ years of germline variant interpretation and 1+ years of somatic variant interpretation experience)
Hands-on experience working with human mutation databases (COSMIC, ClinVar, OncoKB), functional annotation sources (dbSNP), and genome browsers (UCSC)
Familiarity with IGV and BAM file analysis and data-minded willingness to learn to use basic bioinformatics tools, with technically minded insights
Knowledge of cancer somatic mutation and signaling pathways (e.g., which mutations have FDA approved drugs, Phase II/III clinical trials, which mutations are considered “hot targets” for drug development, etc.)
Exceptional attention to detail to follow highly detailed SOPs and strong organizational skills to track and manage clinical reporting and product improvement projects
Excellent communication skills and ability to work collaboratively with cross-functional teams
Operationally-defined flexible schedule, including weekends, as dictated by clinical reporting needs
Benefits
Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
Open, transparent culture that includes weekly Town Hall meetings
The ability to indirectly or directly change the lives of hundreds of thousands patients
Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
Supplemental fertility benefits coverage
Retirement savings program including a 4% Company match
Increase paid time off with increased tenure
Latest and greatest hardware (laptop, lab equipment, facilities)
Generous equity options offering
Corporate bonus program
Industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.)
Company
BillionToOne
BillionToOne is a precision diagnostics company that focuses on genetic testing for disease detection.
501-1000 employees
H1B Sponsorship
BillionToOne has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (7)
2024 (6)
2023 (3)
2022 (2)
2021 (1)
2020 (2)
Funding
Current Stage
Public CompanyTotal Funding
$425.9MKey Investors
Premji InvestBridge BankHummingbird Ventures
2025-11-06IPO
2024-06-21Series D· $130M
2022-12-15Series C· $48.5M
Leadership Team
J
Jean Hayden
VP of Operations and Chief of Staff to the CEO
Oguzhan Atay
Co-founder and CEO
Recent News
Norwest
2025-12-31
2025-12-10
Company data provided by crunchbase