General Proximity · 3 months ago
Scientist/Sr. Scientist, Medicinal Chemistry
San Francisco, CA
Full-time
Onsite
Mid, Senior LevelGeneral Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). They are seeking an experienced medicinal chemist to be a founding member of their Chemistry/Drug Discovery Team, responsible for supervising synthetic efforts, designing bifunctional molecules, and collaborating on patent applications.
Biotechnology
Responsibilities
Supervising synthetic efforts with our CROs
Performing and analyzing in cellulo assays
Designing and optimizing first-in-class bifunctional molecules
Collaborating with our Drug Discovery and IP team on patent applications
Providing input for mechanistic studies on lead drug molecules
Spearheading forays into new disease areas
Qualification
Required
PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field
Industry experience is desirable, but the ability to work hard and learn fast is more important to us
Deep understanding of small-molecule drug discovery and its relationship to human disease
Applicant must be able to work fluently at the interface of chemistry and biology
Top-notch written and oral communication skills
Strong experience with designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)
Contributing to hit-to-lead and lead optimization studies
Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK
Applicant must have experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), PPI assays (e.g., BRET, APEX/BioID, AlphaScreen), or strong experience in computational chemistry
Preferred
Proficiency in HTS and phenotypic assay development
Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc
Computational or molecular dynamics drug discovery experience
DEL experience
Experience managing others, especially synthetic chemistry CRO teams
Prior experience on teams that have successfully advanced research to the clinic
Benefits
Strong equity incentives.
Top tier medical, dental, and vision coverage + One Medical membership.
401(k) retirement plans.
Education and health/fitness incentive programs.
Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.
Reading budget! We will buy you books.
Company
General Proximity
We are hiring for multiple roles; join us on our journey. Visit our website at https://www.generalproximity.bio.
Founded in 2019
11-50 employees
H1B Sponsorship
General Proximity has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2021 (2)
Funding
Current Stage
Early StageTotal Funding
unknown2022-01-01Seed
2020-03-01Pre Seed
Leadership Team
Armand Cognetta
Founder/CEO
Recent News
Google Patent
2025-02-16
Company data provided by crunchbase