Vaxcyte · 3 months ago
Senior Engineer, Polysaccharide Downstream Process Development
San Carlos, California, United States
Full-time
Onsite
Senior Level
$157K/yr - $183K/yr
5+ years expVaxcyte is a clinical-stage vaccine innovation company focused on developing high-fidelity vaccines to combat bacterial diseases. They are seeking a Senior Engineer to contribute to the Polysaccharide development and manufacturing group, where the successful candidate will design and execute experiments for downstream processes and collaborate closely with the CMC team.
BiopharmaBiotechnologyHealth Care
Responsibilities
Design and execute experiments to further develop downstream processes including:
Continuous centrifugation and depth filtration development
TFF optimization and characterization
Chromatography screening, optimization, and characterization
Scaling studies
Development of scale-down model for unit operations
Lead initiatives and tasks for downstream process characterization studies
Operate and maintain instrumentation for polysaccharide purification including automated TFF systems, Akta chromatography skids, automated filtration units and continuous centrifuges
Perform analysis and interpret results for polysaccharide and impurity assays (Anthrone, Lowry, SEC-MALS, HPAEC-PAD)
Keep accurate and current records of development experiments and/or project related activities in laboratory notebooks or electronic notebook, prepare technical reports, summaries of testing, and detailed protocols
Present/communicate data to polysaccharide team as well as cross-functional teams
Research literature to identify novel methodologies and solve scientific problems which apply to the overall program
Review executed protocols and batch records and support tech transfer purification processes to external manufacturing groups
Writes, reviews, and approves R&D protocols, batch records, and reports in support of process development, and assay development
May have direct reports in the future. Works within a team environment and provides support as necessary to further the team’s initiatives
Qualification
Required
PhD in Bioprocess Engineering, Chemical Engineering, Biotechnology, or a related discipline, with a minimum of 5 years of industry experience or combination of industry and postdoctoral research; M.S. with a minimum of 10 years of industry experience; or B.S. with a minimum of 13 years of industry experience
Strong understanding of the principals of DOE (Design of Experiments); practical experience with DOE software; proficient in the design and interpretation of statistically modelled experiments
In-depth late-stage process characterization development experience (Risks assessments, CPP Identification, PAR, PC study report writing)
Practical experience with and theoretical knowledge of traditional processing unit operations including TFF, depth filtration, continuous centrifugation, and chromatography
Demonstrated leadership on a project initiative and/or management of a team. Has successfully worked in a cross-functional team environment on multiple projects; ability to work effectively as a member of a team to deliver results
Proficient with engineering principles involved in scaling processes from lab to pilot scale as well as developing a scale-down model
Proficient with computer programs such as JMP, Microsoft Excel, Word, PowerPoint, Visio
Working knowledge of the requirements of GMPs
Experience working with CDMOs and ability to effectively communicate experimental design and results to a CDMO
Ability to travel internationally to a CMO as some international travel may be required
Strong interpersonal skills, with excellent written and verbal communication skills
Preferred
Technical knowledge and experience using Tecan Fluent instrumentation and generating scripts for high throughput screening application is a plus
Prior experience in polysaccharide development is a plus
Benefits
Comprehensive benefits
An equity component
Company
Vaxcyte
Vaxcyte focuses on developing vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide.
201-500 employees
H1B Sponsorship
Vaxcyte has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (14)
2024 (7)
2023 (5)
2022 (7)
2021 (2)
Funding
Current Stage
Public CompanyTotal Funding
$3.85BKey Investors
CARB-XTPG GrowthAbingworth
2024-09-04Post Ipo Equity· $1.5B
2024-01-30Post Ipo Equity· $862.5M
2023-04-19Post Ipo Equity· $500M
Leadership Team
Andrew Guggenhime
President & Chief Financial Officer
Jeff Fairman
Founder and Vice President, Research
Recent News
2025-12-09
Company data provided by crunchbase