Eli Lilly and Company · 7 hours ago
Sr. Principal Process Engineer - Oligonucleotides
Houston, TX
Full-time
Onsite
Senior Level, Lead/Staff
5+ years expEli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, dedicated to improving lives through innovative medicines. The Senior Principal Process Engineer will provide technical leadership in small molecule or peptide manufacturing, focusing on mentoring engineers, optimizing processes, and supporting the startup of a new manufacturing facility.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Mentor process engineers in core engineering practices for oligonucleotide API supply
Promote data-driven decision-making using statistical methods and first principles
Support and review root cause analyses and technical documentation
Identify and address process knowledge gaps affecting equipment and process performance
Capture key process knowledge such as material and energy balances, kinetics, and design basis
Maintain process safety foundations and support hazard reviews
Ensure equipment qualification aligns with intended use and remains valid after changes or maintenance
Integrate modeling and simulation to enhance process understanding and control
Drive continuous improvement in equipment and processes as part of cross-functional teams
Lead or support tech transfer of new processes and unit operations
Oversee development of user requirements, design reviews, and verification plans
Guide return-to-service protocols following equipment interventions
Qualification
Required
Bachelor's Degree in Process, Chemical, Biochemical Engineering or related applicable STEM discipline
5+ years of experience in API Manufacturing Unit Operations
Preferred
Experience with API chemical synthesis, biotech operations, and chromatography
Familiar with GMP production environments
Strong foundation in chemical engineering and technical problem-solving
Able to work independently and within cross-functional teams
Skilled in coaching and mentoring for technical development
Proactive in identifying and implementing improvements
Flexible and responsive to evolving business needs
Benefits
Company-sponsored 401(k)
Pension
Vacation benefits
Eligibility for medical, dental, vision and prescription drug benefits
Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
H1B Sponsorship
Eli Lilly and Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (514)
2024 (236)
2023 (167)
2022 (133)
2021 (57)
2020 (52)
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
2026-01-16
2026-01-16
Company data provided by crunchbase