Gilead Sciences · 21 hours ago
Scientist, Biology
San Francisco Bay Area
Full-time
Onsite
Mid, Senior Level
$147K/yr - $190K/yr
4+ years expGilead Sciences is dedicated to creating a healthier world for all people through innovative therapies. They are seeking a highly motivated Research Scientist to contribute to biophysics capabilities, enabling the identification and nomination of drug candidates across various therapeutic areas.
BiopharmaBiotechnologyHealth CareManufacturingPharmaceutical
Responsibilities
Apply steady-state and pre-steady-state kinetic assays to characterize enzyme targets and inhibitor mechanism of action
Experience with mass spectrometry-based and biosensor approaches for lead ID characterization of novel and traditional drug modalities including PROTACs, molecular glues and covalent inhibitors
Strong technical background in cellular assay development and signaling pathways
Must be both a critical and creative thinker and be able to apply an advanced level of understanding and analytical skills to interpret data and draw conclusions within the broader context of project goals
Able to troubleshoot and optimize assays as needed, identifying, and applying novel techniques or proactively seeking out solutions
Perform critical experiments to enable hit identification and lead optimization across therapeutic modalities
Provide scientific insight and in-depth data interpretation to inform decision making at the project team and leadership levels
Evaluate and implement new technologies to support advancement of internal programs and core group functions
Contribute to several projects at any given time, work successfully in a cross-functional team environment, and communicate clearly both verbally and in writing to a variety of audiences
Qualification
Required
Bachelor's Degree and 6 years experience
Master's Degree and 4 years experience
PhD /PharmD
Apply steady-state and pre-steady-state kinetic assays to characterize enzyme targets and inhibitor mechanism of action
Experience with mass spectrometry-based and biosensor approaches for lead ID characterization of novel and traditional drug modalities including PROTACs, molecular glues and covalent inhibitors
Strong technical background in cellular assay development and signaling pathways
Must be both a critical and creative thinker and be able to apply an advanced level of understanding and analytical skills to interpret data and draw conclusions within the broader context of project goals
Able to troubleshoot and optimize assays as needed, identifying, and applying novel techniques or proactively seeking out solutions
Perform critical experiments to enable hit identification and lead optimization across therapeutic modalities
Provide scientific insight and in-depth data interpretation to inform decision making at the project team and leadership levels
Evaluate and implement new technologies to support advancement of internal programs and core group functions
Contribute to several projects at any given time, work successfully in a cross-functional team environment, and communicate clearly both verbally and in writing to a variety of audiences
Preferred
Ph.D. with a minimum of 2 years of experience, or an M.Sc. with 5-7 years of experience in in biochemistry, enzymology, biophysics or a related scientific discipline and direct experience in assay development and/or inhibitor mechanism of action studies
Background in classical enzymology and biophysics (SPR ITC, MST, KinExA), including steady-state and pre-steady-state kinetics, thermodynamics, and reaction mechanism
Expertise in a broad range of assay formats including activity assays, competitive binding assays, and direct binding assays to identify and characterize small molecules and biologics
Practical experience applying mass spec approaches for drug discovery and experience studying covalent and degrader small molecule modalities would be advantageous
Strong analytical skills and a solid understanding of rate equations and data fitting statistics
Excellent verbal and written communication skills to disseminate information to direct colleagues and broad audiences
Track record of productivity in diverse work environments
The candidate should be able to think critically and creatively across multiple disciplines and have demonstrated the ability to answer complex scientific questions using a variety of biophysical techniques e.g. mass spectrometry
Experience with automation is a definite plus
Must be detail-orientated and extremely well-organized
Strong interpersonal and communication skills, with enthusiasm for working in a driven environment characterized by rigorous scientific and innovative thinking
Excellent written and oral organizational skills
Benefits
Discretionary annual bonus
Discretionary stock-based long-term incentives (eligibility may vary based on role)
Paid time off
Company-sponsored medical, dental, vision, and life insurance plans
Company
Gilead Sciences
Gilead Sciences is a biopharmaceutical company that discovers, develops, manufactures and commercializes therapies for critical diseases.
10001+ employees
H1B Sponsorship
Gilead Sciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (269)
2024 (241)
2023 (222)
2022 (208)
2021 (235)
2020 (187)
Funding
Current Stage
Public CompanyTotal Funding
$4.41BKey Investors
Abingworth
2024-11-13Post Ipo Debt· $3.5M
2024-02-29Post Ipo Equity· $210M
2023-09-07Post Ipo Debt· $2B
Leadership Team
Keeley Wettan
Senior Vice President, Legal
Patrick Loerch
Senior Vice President, Clinical Data Science
Recent News
2026-01-09
2026-01-08
2026-01-07
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