Kernal Biologics · 3 months ago
Principal Scientist, LNP Formulation
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
4+ years expKernal Bio is a biotech company focused on engineering human cells using mRNA-LNP technology to treat cancer and autoimmune diseases. They are seeking a highly motivated Principal Scientist to develop and characterize lipid nanoparticle formulations, support tech transfer to external partners, and analyze experimental results in a dynamic environment.
BiotechnologyPharmaceuticalTherapeutics
Responsibilities
Develop and characterize novel LNP formulations and components using Dynamic Light Scattering, Ribogreen, HPLC, etc
Support the design and execution of flow cytometry-related experiments pertaining to LNP screening and optimization
Screen final formulation buffers and excipients to improve the long-term stability of LNPs
Execute in vivo experiments with LNP compositions
Develop new assays or detailed investigations of specific LNP attributes as required
Development, optimization, and troubleshooting of LNP/mRNA manufacturing processes at various scales
Analyze, summarize, and present experimental results to team members and management
Contribute to maintaining stocks and supplies for operations within the LNP Formulation team
Participate in technology transfer activities related to manufacturing processes and/or analytical methods to external partner programs
Maintain up-to-date records and prepare internal reports
Contribute to technical discussions & intellectual property related to the development and application of Kernal’s proprietary technologies
Qualification
Required
PhD in Chemical Engineering, Biomedical Engineering, Bioengineering, Pharmaceutics, Chemistry or related field
PhD with 4 years of industry experience in process development in the context of lipid nanoparticles, polymeric nanoparticles, or similar
Experience in manufacturing LNPs using Microfluidics, T-mixer, or other inline mixers
Experience with tangential flow filtration (TFF) and sterile filtration
Proficiency with related LNP/mRNA analytical techniques (e.g. plate-based fluorescence assays, HPLC, LC/MS)
Proficiency with in vivo LNP testing (IV administration, IVIS imaging, etc.)
Proficiency with biological assays critical for identifying key characteristics or properties of lipid nanoparticles
Familiarity with ELN and GraphPad Prism
Experience with process modeling and Design of Experiment (DoE) statistical tools
Preferred
Experience with flow cytometry principles and executing experiments
Experience with tech transfer to GMP manufacturing
Attention to detail, ability to multi-task, and complete deliverables within timelines
Strong written and verbal communication skills
Adaptability and enthusiasm for new challenges and a passion for learning in a fast-paced startup setting
Ability to work independently while effectively interacting and collaborating in a team environment
Benefits
Competitive 401(k)
Highly competitive healthcare coverage (PPO/HMO)
Free parking, a monthly subway pass, or a subsidized commuter rail pass
Free Bluebike Membership
Gym Membership Support
Flexible Spending Account
Paid parental leave, family caregiver leave, and medical leave
Paid life insurance coverage
On-site cafeteria
Competitive vacation and sick days per year
Company
Kernal Biologics
Kernalbio creates mRNA therapies that instruct specific cells on how to make their own medicine.
11-50 employees
H1B Sponsorship
Kernal Biologics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (1)
2024 (2)
2021 (1)
Funding
Current Stage
Early StageTotal Funding
$73MKey Investors
Advanced Research Projects Agency for HealthHummingbird Ventures
2025-10-07Grant· $48M
2022-07-07Series A· $25M
2020-10-21Seed
Leadership Team
B
Burak Yilmaz
Founder & President
Recent News
Google Patent
2025-02-08
Company data provided by crunchbase