Revolution Medicines · 2 weeks ago
Executive Director, Computational Systems Biology
San Francisco Bay Area
Full-time
Onsite
Director/Executive
$256K/yr - $320K/yr
15+ years expRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies for RAS-addicted cancers. The Executive Director will oversee the scientific and strategic direction of systems biology research and preclinical computational biology initiatives, leading a team to analyze large multi-omics data sets to inform treatment strategies.
Health CareLife ScienceMedical
Responsibilities
Develop and implement a long-term strategy for research systems biology and bioinformatic activities to support a growing pipeline of RAS(ON) and novel targeted inhibitors
Lead and supervise a team of experienced computational biologists and bioinformaticians to generate, organize, and interpret large data sets to inform therapeutic and combination strategies for patients with cancer
Work across functions to support advancement of programs from early discovery into clinical development using biological insights derived from computational approaches
Leverage clinical data from RVMD investigational agents to generate proprietary insights into RAS mutant tumor biology and RVMD RAS(ON) inhibitor mechanisms of action
Lead a team analyzing large, high-dimensional datasets
Work with colleagues in Information Sciences and Information Systems to oversee data integration, analysis and visualization using cloud-based platforms (AWS, Azure, GCP)
Direct the development and application of cutting-edge statistical analysis, AI/ML methods, generative AI models, and MLOps principles to elucidate findings and generate new insights related to biomarker discovery, drug target identification, and predictive modeling
Establish and implement modern workflow management systems (Snakemake, Nextflow) and reproducible research practices
Cultivate and manage academic and industry collaborations, including CRO partnerships
Represent the company at scientific conferences through presentations and thought leadership
Maintain an active publication record in high-impact, peer reviewed journals
Drive intellectual property strategy and patent filings related to computational discoveries
Qualification
Required
A Ph.D. in systems biology, computational biology, bioinformatics, or a related biological or biomedical discipline
Minimum of 15+ years total experience with significant pharmaceutical/biotechnology industry and management experience
Deep expertise in systems biology, computational biology, and bioinformatics, including proficiency with multi-omics data integration, modeling, and analysis
Experience with single-cell technologies, spatial transcriptomics, proteomics, and epigenomics
Advanced programming skills in R, Python, and at least one additional language (Perl, C/C++, Java)
Proficiency with high-performance computing (HPC) and cloud platforms (AWS, Azure, or GCP)
Knowledge of workflow management tools and version control systems
Understanding of MLOps principles, model deployment, and generative AI applications in drug discovery
Demonstrated ability to lead, mentor, and inspire interdisciplinary teams while fostering a collaborative culture
Experience managing budgets and strategic planning at the department level
Proven track record of advancing research programs from discovery through development
Proven strategic thinker who can align research and drug development objectives and leverage innovative technologies effectively
Excellent communication and presentation skills for interacting with technical teams, senior leadership, and external partners
Preferred
Oncology research experience preferred but not required
Benefits
Competitive cash compensation
Robust equity awards
Strong benefits
Significant learning and development opportunities
Company
Revolution Medicines
Revolution Medicines is an innovative and dynamic organization of expert biologists, chemists, pharmacologists, clinical scientists.
501-1000 employees
H1B Sponsorship
Revolution Medicines has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (13)
2024 (18)
2023 (15)
2022 (8)
2021 (1)
2020 (2)
Funding
Current Stage
Public CompanyTotal Funding
$2.25BKey Investors
Royalty PharmaBoxer CapitalNextech Invest
2025-06-24Post Ipo Debt· $250M
2024-12-02Post Ipo Equity· $750M
2023-03-02Post Ipo Equity· $323.6M
Leadership Team
Luan Wilfong
Chief Human Resources Officer
Steve Kelsey
President
Recent News
Pharmaceutical Technology
2026-01-13
Company data provided by crunchbase