Apply on Employer Site

Denali Therapeutics · 2 days ago

Senior Scientist, Clinical Pharmacology

South San Francisco, CA

Full-time

Onsite

Senior Level

$142K/yr - $198K/yr

5+ years exp

Denali Therapeutics is a biotechnology company focused on developing breakthrough therapies for neurodegenerative diseases. The Senior Scientist in Clinical Pharmacology will be responsible for developing clinical pharmacology strategies, designing clinical studies, and analyzing pharmacokinetic data to support drug development and regulatory submissions.

BiotechnologyGeneticsHealth DiagnosticsTherapeutics

H1B Sponsor Likely

Responsibilities

Develop Clinical Pharmacology and M&S strategies for multiple biotherapeutics and small molecule programs from pre-IND through late-stage clinical studies, including pivotal Phase 2/3 trials and NDA/MAA/BLA submissions

Develop clinical study designs and write study protocols, amendments, and reports that meet regulatory standards and project timelines with minimal supervision

Conduct hands-on pharmacokinetic (PK) and pharmacodynamic (PD) data analysis using advanced tools and methodologies to support clinical decision-making

Analyze, interpret, and communicate PK/PD data to project teams, senior leadership, and regulatory authorities

Author and review sections of regulatory submissions, including IND/CTA and NDA/MAA/BLA filings

Qualification

Clinical PharmacologyPK/PD data analysisM&S strategiesBiotherapeutics experienceNeuroscience backgroundAnalytical skillsCommunication skillsCollaboration skills

Required

PhD or PharmD in Pharmaceutical Sciences, Pharmacokinetics, Pharmacology, or related scientific discipline with 5+ years experience in Clinical Pharmacology and drug development; may include relevant postdoctoral experience

Proficiency in quantitative PK/PD data analysis tools (e.g., Phoenix WinNonlin, population PK analysis, exposure-response analysis, and/or PBPK modeling)

Experience in developing Clinical Pharmacology and M&S strategies, with biotherapeutics experience preferred

Strong analytical and communication skills for presenting complex PK/PD data

Proven ability to collaborate effectively on cross-functional teams

Preferred

Experience in developing Clinical Pharmacology and M&S strategies, with biotherapeutics experience preferred

Background in neuroscience indications and/or oligonucleotide drug development preferred

Benefits

401k

Healthcare coverage

ESPP

A broad range of other benefits

Company

Denali Therapeutics

Denali Therapeutics is dedicated to defeating neurodegenerative diseases to deliver safe and effective medicines to patients and families.

Founded in 2013

San Francisco, California, USA

501-1000 employees

https://www.denalitherapeutics.com

H1B Sponsorship

Denali Therapeutics has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (11)

2024 (14)

2023 (7)

2022 (6)

2021 (5)

2020 (1)

Funding

Current Stage

Public Company

Total Funding

$1.32B

Key Investors

Royalty PharmaBaillie Gifford

2025-12-04Post Ipo Debt· $200M

2024-02-27Post Ipo Equity· $500M

2022-10-19Post Ipo Equity· $275M

Leadership Team

Ryan Watts

CEO

Peter Chin

Sr. Vice President & Head of Late-Stage Clinical Development and Medical Affairs

Recent News

Longevity.Technology

NEJM publishes Phase 1/2 study of Denali’s tividenofusp alfa in Hunter syndrome

2026-01-03

MarketScreener

The New England Journal of Medicine Publishes Phase 1/2 Study of Denali Therapeutics’ Tividenofusp Alfa (DNL310) for Hunter Syndrome (MPS II)

2025-12-30

thefly.com

Denali Therapeutics announces publication of Phase 1/2 study of DNL310

2025-12-30

Company data provided by crunchbase