Alamar Biosciences, Inc. · 5 hours ago
Sr. Mechanical Engineer
Fremont, CA
Full-time
Onsite
Senior Level
$150K/yr - $170K/yr
6+ years expAlamar Biosciences, Inc. is focused on enabling scientific discoveries that translate into clinical outcomes. As a Senior Mechanical Engineer, you will sustain the current proteomics instrument platform and drive the development of next-generation systems while collaborating with cross-functional teams to optimize performance and innovate solutions.
BiotechnologyHealth CareMedical
Responsibilities
Sustaining Engineering: Own mechanical reliability improvement projects (life testing, FMEA updates, failure analysis)
Drive design changes via ECOs and partner with Manufacturing to validate fixes
Next-Generation Development: Build and bring‑up alpha/beta prototypes; define verification methods (gage R&R, test fixtures, acceptance criteria) and analyze results to iterate designs
Partner with Systems/Software/Vendor to integrate sensors/actuators; define interfaces, alignment/adjustment schemes, and calibration methods
CAD: Develop and maintain 3D CAD models and assemblies using SolidWorks. Release production drawings with full GD&T and critical‑to‑quality callouts
Hands-On Execution: Perform assembly, testing, and debugging in lab settings using diagnostic tools and equipment to verify functionality. Develop and validate testing or manufacturing fixtures
Documentation: own BOMs, CAD, and production drawings with full GD&T; ensure change of traceability, serviceability, backwards compatibility and smooth change management with CM
Manufacturing Integration: Identify advanced materials, suppliers and processes (e.g., injection molding, CNC machining, sheet metal fabrication) to improve cost-efficiency and system robustness
Qualification
Required
Bachelor's or Master's degree in Mechanical Engineering, Mechatronics, or a related field
6+ years in mechanical engineering for biotech instrumentation, medical devices, or life sciences platforms (e.g., NGS sequencers, PCR analyzers, or protein detection systems), with expertise in both sustaining and developing complex electro-mechanical systems
Expert in 3D CAD modeling (SolidWorks preferred)
Experience designing precision gantry systems (e.g., XY/XYZ): linear guides, belts/lead screws/ball screws, stepper/BLDC drives, kinematics and backlash management, alignment/calibration methods, tolerance analysis, and safety/interlocks
Expertise in mechanisms, materials, GD&T, and tolerance analysis
Proficiency in structured problem-solving, verification/validation (V&V), and risk management processes
Excellent analytical, problem-solving, written, and verbal communication skills
Ability to collaborate across disciplines and present technical concepts clearly to non-experts
Proactive, adaptable, and thrive in a fast-paced startup environment with a strong sense of ownership
Preferred
Demonstrated ownership from concept → V&V → transfer to manufacturing → sustaining for a complex instrument or subsystem
Background in machined, sheet metal, and injection molded parts and their production tooling
Experience with biotech-specific challenges, such as integrating consumables, liquid-handling, or thermal control in high-throughput instruments
Knowledge of ISO 13485 and other regulatory standards for medical devices or diagnostics
Benefits
Bonus
Equity
Benefits
Company
Alamar Biosciences, Inc.
Alamar Biosciences is powering precision proteomics with automated, high throughput solutions for ultra-high sensitivity protein analysis across a range of multiplex levels.
51-200 employees
H1B Sponsorship
Alamar Biosciences, Inc. has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (5)
2024 (6)
2023 (4)
2022 (3)
2021 (3)
Funding
Current Stage
Growth StageTotal Funding
$282MKey Investors
Alzheimer's Drug Discovery FoundationSands Capital VenturesSherpa Healthcare Partners
2026-01-11Convertible Note· $50M
2025-01-08Grant· $10M
2024-02-26Series C· $128M
Leadership Team
Yuling Luo
Founder, Chairman & CEO
Yiyuan Yin
Co-founder and VP of Technology
Recent News
2026-01-14
Company data provided by crunchbase