Legend Biotech · 2 days ago
Senior Scientist/Principal Scientist, Quantitative Pharmacology
Somerset, NJ
Full-time
Hybrid
Senior Level, Lead/Staff
7+ years expLegend Biotech is a global biotechnology company dedicated to treating life-threatening diseases. The Senior Scientist/Principal Scientist in Quantitative Pharmacology will lead modeling and simulation efforts in support of gene and cell therapy products, focusing on QSP and popPK modeling.
BiotechnologyHealth CareLife ScienceOncologyTherapeutics
Responsibilities
Lead QSP and popPK modeling activities across preclinical and clinical development stages
Play a pivotal role in shaping clinical pharmacology strategies, supporting regulatory submissions, and driving innovation in model-informed drug development (MIDD)
Develop and apply mechanistic models to understand disease pathways, drug mechanisms, and patient variability
Conduct simulations to support dose selection, trial design, and exposure-response analyses
Collaborate cross-functionally with R&D, clinical, regulatory, and biostatistics teams
Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs)
Contribute to scientific publications and conference presentations
Qualification
Required
MS/PhD/Pharm D in Pharmaceutical Sciences, Clinical Pharmacology, Applied Mathematics, Biomedical Engineering, or related quantitative discipline
7+ years with MS degree or 3+ years with PhD/Pharm D degree of working experience in quantitative pharmacology or pharmacometrics in pharmaceutical companies or CRO companies
Have strong execution ability
Strong independent scientific research ability, logical thinking, and coordination/problem-solving skills
Have clear written and oral communication skills
Have a good team spirit
Demonstrated expertise in QSP and popPK modeling, including proficiency with tools such as NONMEM, R, MATLAB, Monolix, etc
Deep understanding of PK/PD principles, translational medicine, and the role of quantitative pharmacology and model-informed drug development (MIDD) in clinical trials and drug development
Demonstrated ability and experience in applying modelling and simulation approaches to enable rational and efficient preclinical and clinical drug development
Familiar with regulatory requirements and guidelines of clinical pharmacology
Good project management skills, and the ability to collaborate with other departments and manage with internal and external partners
Proven track record of scientific contributions through publications or presentations
Good personality, honest and trustworthy
Physically and mentally healthy, love life
Preferred
Prior cell and gene therapy experience preferred
Benefits
Medical, dental, and vision insurance
401(k)-retirement plan with company match that vest fully on day one
Equity and stock options are available to employees in eligible roles
Eight weeks of paid parental leave after just three months of employment
Paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays
Flexible spending and health savings accounts
Life and AD&D insurance
Short- and long-term disability coverage
Legal assistance
Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
Commuter benefits
Family planning and care resources
Well-being initiatives
Peer-to-peer recognition programs
Company
Legend Biotech
Legend Biotech is a biopharmaceutical company that develops and commercializes novel cell therapies for oncology.
1001-5000 employees
H1B Sponsorship
Legend Biotech has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (30)
2024 (11)
2023 (14)
2022 (7)
2021 (6)
2020 (13)
Funding
Current Stage
Public CompanyTotal Funding
$750.45M2023-05-05Post Ipo Equity· $350M
2022-07-25Post Ipo Equity· $250M
2020-06-05IPO
Leadership Team
Carlos Santos
Chief Financial Officer
Alan Bash
President, CARVYKTI
Recent News
2025-12-18
thefly.com
2025-12-09
Company data provided by crunchbase