Calico Life Sciences · 3 months ago
Medical Director / Senior Medical Director
South San Francisco, CA
Full-time
Onsite
Senior Level, Lead/Staff, Director/Executive
$335K/yr - $400K/yr
5+ years expCalico Labs is a research and development company focused on understanding human aging and improving health span. The Medical Director/Senior Medical Director will provide strategic input for translational and clinical development projects related to neurological and neuropsychiatric indications.
Responsibilities
Leads cross-functional teams which develop the strategy to translate preclinical mechanistic data to humans and to develop translational biomarkers for novel targets in neurological/neuropsychiatric indications
Actively interfaces with research and drug development leaders, at Calico and outside of Calico, to inform disease indication strategies for novel targets
Utilizes clinical expertise to guide the development and utilization of preclinical models in close collaboration with discovery and biomarker scientists at Calico and Calico’s business partners
Works closely with other drug developmental functional areas to shape new clinical programs at multiple points in their evolution, with an emphasis on translational/early clinical development (Phase 0 through Phase 2)
Designs and executes experimental medicine studies to demonstrate proof-of-mechanism of novel targets in neuropsychiatric diseases
Designs and executes early clinical development plans to demonstrate proof-of-concept in various neuropsychiatric indications
Provides scientific/medical content and other input as appropriate for protocols, Investigator Brochures, Clinical Study reports, regulatory submissions and responses, and other program documents
Qualification
Required
Scientifically minded Physician (M.D.) or Physician-Scientist (M.D./Ph.D.)
At least 5 years of translational, clinical trial, or drug development experience in the biotech/pharmaceutical industry, academia, or equivalent
Board-certified/eligible in Neurology and/or Pediatric Neurology highly preferred
Clinical/translational research and/or drug development experience across various neuropsychiatric disease areas
Medical knowledge in treating patients across various neuropsychiatric or neurological indications
Working knowledge or direct experience in early clinical trial methodology (Phase 0, Phase 1, Phase 2)
Proven leadership skills and ability to bring out the best in others on a cross-functional team
Able to provide effective leadership through influence in a highly matrixed environment, including various drug development functions within Calico and its development partners
Must possess excellent oral and written English communication skills
Must be willing to work onsite at least 4 days a week
Preferred
Board-certified/eligible in Neurology and/or Pediatric Neurology
Benefits
Two annual cash bonuses
Company
Calico Life Sciences
Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies.
201-500 employees
H1B Sponsorship
Calico Life Sciences has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (12)
2024 (12)
2023 (7)
2022 (10)
2021 (5)
2020 (14)
Funding
Current Stage
Growth StageLeadership Team
Ashley Archuleta
Sr. Administrative Assistant to the Chief Business Officer
Jonathan Lewis
Chief Business Officer
Recent News
Research & Development World
2026-01-23
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2025-11-15
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