Schrödinger · 2 months ago
Senior Principal Scientist / Director, Medicinal Chemistry
Schrödinger is seeking a Senior Principal Scientist or Director of Medicinal Chemistry to enhance their drug discovery efforts using advanced computational methods. The role involves leading drug discovery programs, executing medicinal chemistry strategies, and collaborating with cross-functional teams to deliver clinical candidates.
BiotechnologyEnterprise SoftwarePharmaceuticalSoftware
Responsibilities
Lead drug discovery programs in effective collaboration with cross-functional teams
Execute medicinal chemistry strategies to deliver high-quality clinical candidates
Collaborate effectively with computational chemists and modelers on the application of Schrödinger’s computational platform for rapid advancement of drug discovery programs
Drive continuous improvement and implementation of new strategies for our Therapeutics Group’s experimental hit-finding capabilities
Provide strategic and technical expertise to the Medicinal Chemistry team and the broader Therapeutics Group
Qualification
Required
PhD in synthetic organic or medicinal chemistry
At least eight years of drug discovery experience in a pharmaceutical and/or biotech setting
Demonstrated track record in medicinal chemistry, as evidenced by successful advancement of drug discovery projects to clinical candidate nomination
Excellent understanding of biology, pharmacology, drug metabolism and pharmacokinetics
Demonstrated experience and expertise with modern experimental hit-finding techniques
Extensive experience working with external chemistry teams at CROs
Preferred
Hands-on experience advancing therapeutic modalities beyond small molecules (e.g., degraders, peptides, ADCs)
Benefits
Healthcare (with dental and vision)
401k
Pre-tax commuter benefits
A flexible work schedule
A parental leave program
Catered meals in the office
Over a month of paid vacation time
Company
Schrödinger
Schrödinger is a healthcare-based software company that develops molecular design software for biotech and materials research.
H1B Sponsorship
Schrödinger has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (3)
2021 (1)
2020 (1)
Funding
Current Stage
Public CompanyTotal Funding
$577.22MKey Investors
Bill & Melinda Gates FoundationBill GatesCascade Investment
2024-07-26Grant· $10M
2021-11-18Grant· $4.9M
2020-08-10Post Ipo Equity· $346.5M
Leadership Team
Recent News
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2025-12-20
2025-12-09
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