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Flagship Pioneering · 2 hours ago

Senior Research Associate/Associate Scientist, Preclinical Formulation Development

Cambridge, MA USA

Full-time

Onsite

Mid, Senior Level

$81K/yr - $126K/yr

3+ years exp

Expedition Medicines Inc. is a privately held biotechnology company focused on Protein Editing to transform health care and sustainability. The role involves developing preclinical formulations for small molecules and collaborating with cross-functional drug discovery teams.

FinanceFinancial ServicesVenture Capital

H1B Sponsor Likely

Responsibilities

Execute stage appropriate, fit-for-purpose preclinical formulations preparation (Solutions, suspensions, emulsions, nanoparticles, SEDDS etc.) for oral, and parenteral formulations on a small scale for small molecules

Author protocols describing preparation of formulations for use at internal and external formulation labs

Basic drug substance characterization by using techniques such as HPLC/UPLC, XRPD, DSC and PLM. Assessment of the chemical and physical properties of small molecules, such as solubility, dissolution, particle size and chemical stability

Routine lab support such as buffer and mobile phase preparation, pH meter calibration, basic troubleshooting of lab equipment, and coordinating with external instrument and service vendors. Shipping and receiving samples between internal and external sites

Summarize experimental results and presents at team meetings and department presentations

Author templated memos and reports with limited guidance

Maintain detailed lab notebooks and reports in compliance with GLP/GMP guidelines (as applicable)

Evaluate novel drug delivery systems (e.g., lipid-based, amorphous solid dispersions, spray dry etc.) for poorly soluble compounds

Support transition of formulations from discovery to clinical development (e.g., bridging studies)

Independently design and perform focused experiments that drive progress in cross-functional formulation initiatives

Qualification

Preclinical formulationsHPLCData analysisPharmacokineticsChemistryCollaborationProblem-solvingAdaptabilityCommunication skillsTime management

Required

B.S. or M.S. in Chemistry, Biochemistry, Chemical Engineering, or a related discipline is required

Three years minimum of industry, government or equivalent experience in small molecules formulation or a related field

Hands-on experience with one or more of the following techniques: HPLC, UV-visible, DSC etc

Experience with data analysis using standard software platforms (Excel, Prism etc.)

Practical experience in developing and preparing preclinical formulations (small molecules)

Basic knowledge of physicochemical properties and their relationship to formulation development

Basic knowledge of pharmacokinetics (PK) and biopharmaceutics principles

The ability to manage multiple parallel activities and deliver results to agreed timelines

Ability to do bench work independently

Strong collaboration, problem-solving, and adaptability in fast-paced research environments

Excellent written, oral, and visual communication skills

Excellent time management skills

Benefits

Healthcare coverage

Annual incentive program

Retirement benefits

A broad range of other benefits

Company

Flagship Pioneering

Glassdoor3.3

Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.

Founded in 2000

Cambridge, Massachusetts, USA

501-1000 employees

http://flagshippioneering.com

H1B Sponsorship

Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (8)

2024 (4)

2023 (4)

2022 (4)

2021 (1)