Glyphic Biotechnologies · 3 months ago
(Senior) Director of Chemistry
Berkeley, CA
Full-time
Onsite
Senior Level, Lead/Staff, Director/Executive
$189K/yr - $258K/yr
12+ years expGlyphic Biotechnologies is developing a groundbreaking protein sequencing platform that aims to revolutionize life science discovery. They are seeking a Senior Director of Chemistry to lead the chemistry function, focusing on reagent design, sample preparation innovations, and team building to support their technology development.
BiotechnologyHealth CareLife Science
Responsibilities
Set the long-term chemistry roadmap for protein sequencing (bio/ortho/conjugations, amino acid side chain modifications, N-/C-terminal cleavage, surface chemistry, custom nucleosides, reagent development)
Partner with biology, engineering, microfluidics/automation, and data science to ensure seamless platform integration
Drive intellectual property strategy, competitive landscape analysis, and participate with legal on freedom-to-operate evaluations
Build robust blocking, capping, and wash chemistries to minimize cross-talk and background signal on solid supports, flow cells, or microarray surfaces, ensuring high specificity and sensitivity in downstream detection assays
Utilize high-throughput screening and combinatorial chemistry testbeds to develop robust and reproducible protocols
Innovate front-end chemistries for protein/peptide capture, enrichment, and derivatization
Optimize lysis, digestion, and peptide stabilization protocols that preserve post-translational modifications (PTMs) and support low-input samples
Integrate with orthogonal proteomics (nano LC-MS, …) for validation
Transition discovery-phase reagents to reagent manufacturing
Recruit, mentor, and lead a multidisciplinary chemistry team (synthetic, analytical, biochemical, biophysical)
Define and track OKRs, budgets, and timelines to meet aggressive startup milestones
Foster a collaborative, data-driven culture and integrate closely with cross-functional teams
Qualification
Required
PhD, organic chemistry, chemical biology, biochemistry, or related field
12+ years in reagent or assay development, including 4+ years in leadership
Proven expertise in protein/peptide chemistry (synthesis, purification, bioconjugation)
Strong background in sample-prep chemistry and methods for proteomics, ideally including immunopeptidomics
Ability to develop novel nucleic acid chemistry (new base pairing, new phosphoramidites)
Translate prototypical organic chemistry (photochemistry, redox chemistry) into a biological environment
Proficiency with analytical techniques: HPLC, LC-MS, fluorescence spectroscopy, NMR, etc
Experience with Intellectual property strategy, competitive landscape analysis, freedom-to-operate evaluations
Track record of translating discovery-phase chemistry into scalable, manufacturing-ready or commercial reagents
Prior startup or early-stage company experience
Visionary and hands-on leader who can balance strategic planning with bench-level problem solving
Preferred
Familiarity with single-molecule or next-generation sequencing chemistries and assays
Knowledge of photochemistry, peptide synthesis, amino acid blocking strategies, orthogonal labeling systems
Experience with automation and/or microfluidic reagent delivery systems
History of patent filings and IP portfolio development
Benefits
Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities
Company
Glyphic Biotechnologies
Glyphic Biotechnologies is a biotechnology company that develops a protein sequencing platform.
11-50 employees
Funding
Current Stage
Early StageTotal Funding
$45.78MKey Investors
FoundersX VenturesLongeVCNational Institutes of Health
2025-09-26Series A· $38M
2024-11-25Seed
2024-01-25Seed
Leadership Team
Joshua Yang
Co-Founder and CEO
Daniel Estandian
CTO and Co-Founder
Recent News
Google Patent
2025-05-04
2025-05-04
2025-02-08
Company data provided by crunchbase