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University of Pittsburgh · 2 months ago

Post Doctoral Associate-Bokai Zhu Lab

Pittsburgh, PA

Full-time

Onsite

Senior Level

The University of Pittsburgh's Zhu Laboratory is seeking a highly motivated postdoctoral associate to study the systems biology of proteostasis regulation and biological timing. The role involves developing mathematical models, collaborating with experimental biologists, and applying statistical methods to analyze imaging datasets related to the 12-hour proteostasis oscillator.

Higher Education

H1B Sponsor Likely

Responsibilities

Develop and analyze deterministic and stochastic models (ODEs, stochastic simulations, hybrid models) of the 12-hour proteostasis oscillator

Collaborate closely with experimental biologists to integrate live-cell imaging and transcriptomic data into quantitative frameworks

Apply statistical inference, data assimilation, and/or machine learning methods to extract dynamic parameters from imaging datasets

Design and perform imaging-based assays to monitor stress and UPR dynamics at single-cell resolution, using fluorescent reporters and live-cell microscopy

Present findings at national conferences and contribute to high-impact publications and grant proposals

Qualification

Mathematical modelingComputational modelingLive-cell imagingPythonMATLABMachine learningBayesian inferenceCollaboration skillsCommunication skills

Required

Ph.D. in Systems Biology, Computational Biology, Applied Mathematics, Biophysics, Bioengineering, or a related quantitative field

Proven experience in mathematical or computational modeling (ODEs, stochastic simulations, dynamical systems)

Familiarity with live-cell imaging, image analysis, and single-cell data quantification is strongly desired

Proficiency in Python, MATLAB, or equivalent programming environments for modeling and data analysis

Strong collaborative and communication skills, with enthusiasm for bridging theory and experiment

Preferred

Experience with machine learning, Bayesian inference, or data-driven modeling approaches is advantageous but not required

Company

University of Pittsburgh

Glassdoor3.9

The University of Pittsburgh is a top-ranked, public institution in Pennsylvania and a member of the Association of American Universities of leading research universities.

Founded in 1787

Pittsburgh, PA, US

10001+ employees

https://www.pitt.edu/pittwire

H1B Sponsorship

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