Baylor College of Medicine · 2 weeks ago
Staff Scientist - T-Cell Biology
Houston, TX
Full-time
Onsite
Senior Level, Lead/Staff
$75K/yr - $75K/yr
3+ years expBaylor College of Medicine is seeking a highly motivated Staff Scientist to join their team investigating T-cell dysfunction and immune evasion following allogeneic hematopoietic cell transplantation. The role involves leading mechanistic projects, applying advanced genomic techniques, and collaborating with various teams to dissect regulatory networks and identify therapeutic strategies.
EducationHigher EducationPharmaceutical
Responsibilities
Lead mechanistic studies of donor T-cell dysfunction post-allo-HCT, with a focus on chromatin regulators, histone modifications, and transcriptional/epigenetic drivers of exhaustion
Apply single-cell transcriptomics, epigenomics (ATAC-seq, CUT&Tag), and CITE-seq to map dysfunctional T-cell states in murine models and patient samples
Use CRISPR/Cas9 screening and perturbation approaches to identify novel regulators of T-cell persistence, effector function, and exhaustion
Collaborate with wet-lab and computational teams to integrate multi-omics datasets with clinical outcomes
Mentor trainees and contribute to team science efforts, including multi-PI grants and translational collaborations
Contribute to manuscripts, conference presentations, and grant applications
Perform other job related duties as assigned
Qualification
Required
Doctoral Degree. Experience may not be substituted in lieu of degree
Three years of post doctoral research experience
Preferred
Ph.D. in Immunology, Epigenetics, Computational Biology, or related fields
Strong publication record with first-author papers in relevant areas
Demonstrated expertise in epigenetic/chromatin biology and its role in immune regulation or cancer biology
Hands-on experience with T-cell biology, single-cell approaches, or CRISPR screening
Strong data analysis skills and ability to work collaboratively across experimental and computational projects
Experience studying T-cell exhaustion, GVHD/GVL biology, or allo-HCT models
Knowledge of checkpoint pathways, metabolic regulation, or cytokine signaling in T cells
Background in integrating clinical datasets with mechanistic studies
Familiarity with drug discovery approaches (e.g., PROTACs, epigenetic inhibitors) that may reverse T-cell dysfunction
Benefits
A highly collaborative environment bridging epigenetics, immunology, and cancer therapy.
Access to state-of-the-art single-cell platforms, CRISPR libraries, and mouse models for allo-HCT and leukemia.
Opportunities for professional growth, including mentorship in grant writing.
Company
Baylor College of Medicine
Baylor College of Medicine, located in the Texas Medical Center, is a health sciences university located in Houston, Texas
5001-10000 employees
H1B Sponsorship
Baylor College of Medicine has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (252)
2024 (208)
2023 (164)
2022 (196)
2021 (126)
2020 (136)
Funding
Current Stage
Late StageTotal Funding
$10.85MKey Investors
National Human Genome Research InstituteNational Heart, Lung and Blood InstituteCancer Prevention and Research Institute of Texas
2024-12-05Grant· $3.5M
2024-09-26Grant
2024-09-19Grant
Leadership Team
Paul Klotman
President, CEO and Executive Dean
Peggy Smith
Professir and CEO. Teen Health Clinics
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