Cytokinetics · 1 day ago
Senior Scientist I
San Francisco Bay Area
Full-time
Onsite
Senior Level, Lead/Staff
$162K/yr - $189K/yr
8+ years expCytokinetics is a specialty cardiovascular biopharmaceutical company focused on scientific innovations in muscle biology. The Senior Scientist I will lead bioanalytical and pharmacokinetic studies to support drug development, collaborating with various teams and mentoring junior scientists.
BiopharmaBiotechnologyHealth Care
Responsibilities
Lead the design, execution, and interpretation of bioanalytical (BA) and pharmacokinetic (PK) studies to support preclinical and clinical development
Hand-on and oversee method development, validation, and sample analysis for small molecules, and/or novel modalities (e.g., siRNA, PROTAC) using Sciex LC-MS/MS, Orbitrap, or Q-TOF machines
Perform non-compartmental (NCA) and compartmental PK analysis, PK/PD modeling, and translational pharmacokinetics to guide compound optimization and dosing strategies
Author and review technical reports, regulatory submissions (INDs, NDAs, BLAs), and scientific publications
Collaborate closely with toxicology, clinical pharmacology, CMC, and discovery teams to ensure suitable study design and robust PK/PD understanding of drug candidates
Leveraging specialized ADME/PK skills such as in vitro ADME, in vivo ADME, biotransformation, PK/PD, or physiologically-based pharmacokinetic modeling (PBPK) to impact project progression and decision-making
Manage external CROs for bioanalytical and PK studies, ensuring data quality and regulatory compliance (GLP/GCP)
Mentor junior scientists and contribute to departmental initiatives to enhance scientific and operational excellence
Capable of independently troubleshooting and resolving Sciex LC-MS/MS challenges as they arise in the lab
Qualification
Required
PhD in Pharmacology, Pharmaceutical Sciences, Chemistry, or related field
8+ years of relevant experience in bioanalytical sciences and pharmacokinetics within the pharmaceutical/biotech industry
Deep expertise in LC-MS/MS, Orbitrap, Q-TOF and HPLC methods
Strong background in PK modeling (WinNonlin, Phoenix, NONMEM, R, etc.) and interpretation of PK/PD data
Experience with regulatory submissions (FDA/EMA/ICH guidelines) and working in a GLP/GCP environment
Proven leadership skills with the ability to influence cross-functional teams and mentor junior scientists
Excellent communication, problem-solving, and project management abilities
Familiarity with DMPK principles (metabolism, transporters, drug-drug interactions)
Knowledge of automation and high-throughput bioanalytical techniques
Company
Cytokinetics
Cytokinetics is a biopharmaceutical company developing therapies for debilitating diseases.
501-1000 employees
H1B Sponsorship
Cytokinetics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (8)
2024 (9)
2023 (4)
2022 (6)
2021 (7)
2020 (4)
Funding
Current Stage
Public CompanyTotal Funding
$2.41BKey Investors
Royalty PharmaDeerfieldVulcan
2025-09-16Post Ipo Debt· $650M
2024-05-22Post Ipo Equity· $550M
2024-05-22Post Ipo Debt· $50M
Leadership Team
Robert Blum
President & CEO
Sung Lee
EVP & CFO
Recent News
2025-12-27
2025-12-24
BioWorld Financial Watch
2025-12-24
Company data provided by crunchbase