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Shennon Biotechnologies · 5 hours ago

Scientist / Senior Scientist - TCR engineering and TCE development

San Francisco, CA

Full-time

Onsite

Mid, Senior Level

$120K/yr - $160K/yr

Shennon Biotechnologies is a well-funded biotech startup focused on advancing immunotherapies for cancer and autoimmune diseases. They are seeking a Senior Scientist with expertise in TCR affinity maturation and T cell engager development to lead engineering efforts and collaborate with an interdisciplinary team.

BiotechnologyLife ScienceMedical

Responsibilities

Design libraries and perform TCR affinity maturation using yeast display

Lead TCR engineering efforts for enhanced affinity, specificity, and stability

Partner with AI/ML scientists to design sequences and libraries, contributing to iterative design-build-test cycles to advance therapeutic candidates

Collaborate with the team to develop TCEs and conduct in vitro functional assays to assess efficacy and safety

Work with CRO on TCR/TCE production and binding characterization

Qualification

TCR affinity maturationT cell engager developmentYeast display technologiesProtein engineeringHigh-throughput screeningTCR/antibody library constructionProtein structure analysisCommunicationCollaboration skillsInitiative

Required

PhD in Biochemistry, Molecular Biology, Bioengineering, Immunology, or a related field

Expertise in yeast display technologies, and high-throughput TCR/antibody screening

Experience in TCR, antibody or protein engineering, including affinity maturation, deep mutational scanning, cross-reactivity, and biophysical property optimization

Experience with TCR/antibody library construction, screening, and binding measurement

Fundamental understanding of TCR/antibody and structure-function relationships

Familiarity with protein structure analysis tools (Pymol, Chimera, MOE)

Ability to work in a fast-paced startup environment, take initiative, and drive projects forward independently

Excellent communication and collaboration skills