Matterworks · 2 months ago
Principal Software Engineer
Somerville, MA
Full-time
Hybrid
Lead/Staff
10+ years expMatterworks is an innovative company focused on building AI tools for biological data insights. The Principal Software Engineer will drive architectural vision and product delivery while collaborating with interdisciplinary teams to solve complex challenges.
Artificial Intelligence (AI)BiotechnologyMedicalPharmaceutical
Responsibilities
Architectural Vision and Strategy: Define and drive the long-term vision for our core software architecture, making critical decisions on infrastructure, product, and platform that span the full stack from low level cloud systems to user-facing interfaces
Product & Platform Development: Lead the end-to-end design and implementation of new capabilities, focusing on high leverage work that derisks existential challenges and enables iterative value delivery in a scaling environment
Engineering Leadership: Provide technical guidance, coordinating cross-team efforts, and building organizational capacity. Stay ahead of industry advancements, applying best practices to elevate our engineering culture and processes
Cross-Functional Collaboration: Work closely with leadership in engineering, AI, product, and scientific discovery to align engineering initiatives with company-wide goals. Use experience to keep initiatives moving smoothly
Mentorship and Guidance: Mentor and develop our team of software engineers, fostering a culture of technical excellence, creativity, and high performance
Qualification
Required
10+ years of professional experience developing software using modern programming languages (e.g., Python, Java, JavaScript), with proven ability to work across the full stack from cloud infrastructure design and debugging to user experience and delivery
Demonstrated experience having led a functional area within a team or organization (e.g., data, platform, or infrastructure engineering)
Proficiency in agile development, with a demonstrated ability to deliver value iteratively while balancing technical depth and business impact
Strong attention to detail with a keen ability to balance priorities while operating with minimal oversight
Industry experience in life sciences, biotechnology, biochemistry, or a related field
Proficient in architecting end to end solutions using a cloud provider (AWS, Azure or GCP)
Proficient in several batch and streaming data processing technologies (Spark, Kafka, Flink, Trino, Airflow, Elasticsearch, SQL etc.)
Demonstrated ability to communicate and collaborate with product, machine learning, applied science and other engineers while reducing complex business questions into valuable, reliable technical solutions
A passion for contributing to an early-stage startup where autonomy, eagerness to learn, and enthusiasm for solving novel scientific challenges prevail over rigid processes and egos
Benefits
Health & dental
Vision
Long- and short-term disability
Life insurance
401k with company match
Flexible work & unlimited time away policy
Commuter benefits and parking
Regular team meals and outings
Company support for continued education/coursework and conference participation
Company
Matterworks
Matterworks is a biotech startup that combines metabolomics with AI to simulate the metabolic environment.
11-50 employees
H1B Sponsorship
Matterworks has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2024 (1)
Funding
Current Stage
Early StageTotal Funding
$13.75MKey Investors
Germin8 Ventures
2025-06-03Series A
2023-08-14Seed· $7.5M
2023-01-01Convertible Note
Leadership Team
Jack (J.M.) Geremia, PhD
Chief Executive Officer
Recent News
globallegalchronicle.com
2025-07-05
2025-06-11
2025-06-11
Company data provided by crunchbase