Guardant Health · 1 month ago
Enterprise Architect (Staff)
Palo Alto, CA
Full-time
Hybrid
Lead/Staff
$171K/yr - $235K/yr
10+ years expGuardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. The company is seeking a strategic and hands-on Enterprise Architect to design and evolve its technology ecosystem, ensuring systems are scalable, secure, compliant, and patient-impact driven while partnering with various teams across the organization.
BiotechnologyHealth CareHealth DiagnosticsOncologyTherapeutics
Responsibilities
Strategic Enterprise Architecture Define and govern Guardant’s enterprise architecture, aligning technology capabilities with business priorities and oncology innovation goals
Reusable Platforms & Components Design shared platforms, modular services, and reusable components that enable faster delivery, reduce duplication, and improve scalability
Scale & Performance Architect cloud-based systems to handle 5x growth in lab throughput, data analytics, and digital engagement within 24 months
Data & Analytics Enablement Define enterprise data strategies and platforms for governance, interoperability, real-time analytics, and AI/ML pipelines
Cloud Transformation Drive an cloud-first architecture (AWS), ensuring resilience, elasticity, security, and cost efficiency at scale
Security & Privacy by Design Embed security and privacy controls into every platform, ensuring compliance with HIPAA, GDPR, CLIA, CAP, and FDA (21 CFR Part 11)
Governance & Standards Establish reference architectures, patterns, and frameworks to reduce technical debt, improve adoption, and enforce consistency across engineering teams
Innovation & Emerging Tech Evaluate and introduce new technologies (e.g., automation, event-driven architectures, AI/ML accelerators) that strengthen Guardant’s competitive edge
Influence & Mentorship Act as a trusted advisor to the engineering leaders, while mentoring architects and engineers across the company
Qualification
Required
10+ years of progressive experience in software engineering and architecture, with 5+ years in enterprise/solution architecture leadership
Bachelor's degree in Computer Science, Management Information Systems, Software Engineering, Electrical Engineering, Computer Engineering, Information Systems, Bioinformatics, or a related technical field required
Proven ability to design and scale digital and enterprise platforms in cloud (AWS) environments
Strong expertise in modular architectures, reusable platforms, and component-driven design
Deep knowledge of security, compliance, and healthcare interoperability standards (e.g., HL7, FHIR, LOINC)
Familiarity with authorization policy frameworks and applying them to flexibly protect assets and resources
Exceptional communication and leadership skills, with ability to influence executives, engineers, and clinical stakeholders
Preferred
Experience with lab informatics, clinical systems, or healthcare data platforms strongly preferred
Experience designing reusable platforms in diagnostics, biotech, or healthcare technology companies
Track record of building enterprise-wide architectures that accelerated delivery while reducing integration complexity
Company
Guardant Health
Guardant Health is a precision oncology company that uses blood tests, data sets, and analytics to provide treatment to cancer patients.
1001-5000 employees
H1B Sponsorship
Guardant Health has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (38)
2024 (50)
2023 (40)
2022 (72)
2021 (57)
2020 (29)
Funding
Current Stage
Public CompanyTotal Funding
$2.53BKey Investors
Baillie GiffordSoftBank Vision FundOrbiMed
2025-11-05Post Ipo Equity· $284.4M
2025-11-05Post Ipo Debt· $350M
2023-12-21Post Ipo Equity· $90.7M
Leadership Team
AmirAli Talasaz
Co-founder and Co-Chief Executive Officer
Helmy Eltoukhy
Chairman and Co-Chief Executive Officer
Recent News
2026-01-03
felicis.com
2025-12-30
Company data provided by crunchbase