NextGen Tides · 3 months ago
Senior Scientist
San Diego, CA
Full-time
Onsite
Senior Level
3+ years expNextGen Tides is an innovative biotech startup focused on oligonucleotide and peptide synthesis. The Principal/Senior Scientist will establish analytical capabilities in separation science and characterization, leading method development and analysis of modified oligonucleotides while working closely with cross-functional teams.
Biotechnology
Responsibilities
Serve as the Lead Oligonucleotide Scientist in cross-functional teams with accountability for oligos purification and analytical analysis
Take a leadership role in maintaining all aspects of analytical/ purification instrumentation and operations in the oligonucleotide laboratory
Develop and maintain standard operating procedures (SOPs) for processing, purification, and analytical characterization to ensure high-quality and reproducible results
Establish and maintain high-throughput automation workflows to support small and mid-scale purification and analysis of ASOs, siRNA, PMO, and ligand-oligo-conjugation with routine and novel next generation amidite synthesis
Establish and routinely perform oligos purification using ÄKTA and analytical characterization workflows
Troubleshoot, operate and oversee the interpretation of data from LC-MS as well as analytical and preparative HPLC
Work closely with synthesis and bioconjugation chemists to develop a seamless workflow to support manufacturing of novel targeting ligands (e.g., peptide, antibody, etc)
With the growth of NextGen Tides, train and/or build a small team of research associates to support oligos purification and analytical analysis capabilities
Supervise and/or lead associates in a cross functional team environment
Demonstrate excellent written and verbal communication skills
Convey novel innovations at the project team level
Qualification
Required
A doctorate degree in Chemistry, Chemical Biology, Organic/Medicinal Chemistry, or a related field
A minimum of 3+ (Senior Scientist) or 6+ (Principal Scientist) years of firsthand industry experience in modern synthetic chemistry methods particularly in nucleosides, nucleotides, and oligonucleotide synthesis, purification, and analysis in pharmaceutical or biotechnology settings
Direct experience setting up and operating different instruments used in oligonucleotides purification (e.g., ÄKTA Avant/Pure with Unicorn Software, tangential flow filtration), analysis (e.g., UPLC, LC/MS, LC/HRMS), and lyophilizes
A dependable contributor to cross-functional teams who embrace a collaborative culture while demonstrating the autonomy and initiative required to deliver on assigned scientific and operational responsibilities
Demonstrated ability to troubleshoot instrumentation and complex scientific problems and adapt to shifting priorities in a fast-paced, quality-driven environment
Preferred
Prior experience in discovery of therapeutic oligonucleotides is highly desirable
Benefits
Equity incentives for high performers
401(k) with employer contribution
Health benefits and family medical coverage
Vacation & PTO policy
Opportunities to grow into principle/VP
Company
NextGen Tides
2-10 employees
Funding
Current Stage
Early StageCompany data provided by crunchbase