Alnylam Pharmaceuticals · 20 hours ago
Executive Director, Pharmacometrics
Cambridge, MA
Full-time
Onsite
Director/Executive
$289K/yr - $391K/yr
10+ years expAlnylam Pharmaceuticals is a leader in RNAi therapeutics, and they are seeking an experienced Head of Pharmacometrics to expand their Clinical Pharmacology and Pharmacometrics capabilities. The Executive Director will provide strategic direction and manage pharmacometric activities, guiding modeling and simulation strategies to support drug development and regulatory submissions.
BiotechnologyHealth CareMedicalPharmaceuticalTherapeutics
Responsibilities
Develop and implement pharmacometric strategies across drug development, including dose selection, study design, and lifecycle management
Provide scientific modeling based input in interpretion and translation of preclinical information to clinical for novel indications and target tissues
Lead and mentor a team of pharmacometricians, ensuring their professional development and providing guidance on complex analyses
Partner with cross-functional teams (early development, clinical research, clinical pharmacology, biostatistics, regulatory affairs) to advance Alnylam portfolio against program goals
Lead the development and application of pharmacometric models to support dosing decisions, optimize trial designs, establish proof of concept and optimize clinical trial success
Engage with regulatory agencies and prepare and review pharmacometric reports and regulatory submission documents
Stay current with advances in pharmacometrics and share expertise within the organization
Qualification
Required
PhD or equivalent in clinical pharmacology, pharmacokinetics, or pharmacometrics
10+ years of pharmaceutical industry experience in drug discovery and development
Expert knowledge of PK/PD, QSP and pharmacometric analyses
Proficient in using modeling software such as R, NONMEM, SAS, MATLAB
Ability to manage multiple programs
Excellent problem solving skills with a strong innovative spirit
Strong leadership and interpersonal skills with experience managing a team of pharmacometricians
Excellent oral and written communication skills
Experience with writing Clinical Pharmacology and Pharmacometrics documents supporting regulatory submissions
Preferred
A robust and rich experience in applying pharmacometric analysis supporting Phase 1-3 clinical development
Benefits
Comprehensive benefits including medical, dental, and vision coverage
Life and disability insurance
A lifestyle reimbursement program
Flexible spending and health savings accounts
A 401(k) with a generous company match
Paid time off
Wellness days
Holidays
Two company-wide recharge breaks
Generous family resources and leave
Company
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.
1001-5000 employees
H1B Sponsorship
Alnylam Pharmaceuticals has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2022 (18)
2021 (19)
2020 (7)
Funding
Current Stage
Public CompanyTotal Funding
$4.55BKey Investors
Blackstone Life SciencesBlackstone CreditRegeneron
2025-09-09Post Ipo Debt· $661.25M
2022-09-12Post Ipo Debt· $900M
2022-03-04IPO
Leadership Team
Yvonne Greenstreet
Chief Executive Officer
Jeff Poulton
Chief Financial Officer
Recent News
2025-12-22
2025-12-20
Company data provided by crunchbase