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Glyphic Biotechnologies · 2 months ago

Senior/Staff Scientist, Surface Chemistry

Berkeley, CA

Full-time

Onsite

Senior Level, Lead/Staff

$120K/yr - $183K/yr

6+ years exp

Glyphic Biotechnologies is pioneering a single-molecule proteome sequencing platform aimed at transforming life science discovery. They are looking for a highly skilled Surface Chemist responsible for developing solid-phase supports for DNA synthesis and protein sequencing, requiring expertise in surface chemistry and analytical techniques.

BiotechnologyHealth CareLife Science

Responsibilities

Develop solid supports that meet the physicochemical performance requirements for a novel single molecule protein sequencing workflow and will be compatible with automation equipment

Source and synthesize custom supports to investigate surface functionalization, porosity, size, stability, and manufacturability

Optimize functionalization chemistries (includes covalent, cleavable, linkers, passivation) to improve interfacial reaction kinetics and efficiency and assay signal-to-noise

Develop and validate analytical methods to characterize/QC solid supports

Develop and validate functional testing methods to characterize/QC solid supports

Partner with scientists and engineers to deploy novel supports into SOP workflows

Design and execute experiments bridging chemistry and molecular biology

Analyze experimental data, generate detailed reports, and provide actionable insights to guide further development

Apply statistical methods and process evaluation tools to ensure workflow quality and performance

Prepare and maintain comprehensive documentation of protocols, SOPs, and results

Contribute to process innovation and support technology transfer as workflows mature

Qualification

Surface chemistrySolid-phase synthesisAnalytical techniquesBioconjugation chemistrySurface modificationFunctional group couplingMorphological characterizationStatistical methodsProblem-solvingCommunicationInterpersonal skillsResourceful adaptabilityCollaborative spirit

Required

Degree in organic chemistry, surface chemistry, bioengineering or equivalent field. Advanced degree preferred

6+ years (PhD), 8+ years (MS), 10+ years (B.S.) of industry or equivalent experience in assay or reagent development

Demonstrated proficiency in surface and morphological characterization (AFM, SEM/TEM, XPS, contact angle, DLS, zeta potential)

Expertise in surface and solid-phase chemistry, including surface modification, functional group coupling (and quantitation), and polymer or nanoparticle surface engineering

Demonstrated proficiency in analytical characterization, including LC–MS, HPLC, FTIR, UV–Vis, fluorescence spectroscopy, and elemental analysis

Hands-on experience with bioconjugation chemistry, such as coupling of proteins, peptides, small molecules, or oligonucleotides via covalent or affinity-based linkers

Excellent problem-solving skills and attention to detail

Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds

Ability to thrive in a fast-paced environment with evolving priorities