Apply on Employer Site

Iambic Therapeutics · 2 months ago

Sr Associate Scientist I or II, GPCR Biology

San Diego HQ

Full-time

Onsite

Mid, Senior Level

$84K/yr - $120K/yr

3+ years exp

Iambic Therapeutics is a clinical-stage life-science and technology company focused on developing novel medicines through an AI-driven discovery platform. They are seeking a Senior Associate Scientist I/II to support in vitro cell-based assays and advance pre-clinical projects in the GPCR Biology group, collaborating with cross-functional teams to enhance small-molecule therapeutics design and discovery.

Artificial Intelligence (AI)Machine LearningSoftwareTherapeutics

Responsibilities

Work closely with the Biology group to independently conceptualize, design and conduct in vitro studies aimed at supporting hit to lead medicinal chemistry efforts targeting GPCRs

Independently manage CRO scientists in the design, development, and implementation of in vitro assays for the advancement of GPCR projects

Execute weekly cell-based assays to screen/evaluate small molecule compounds in coordination with Biology, Chemistry, and Compound Management groups

Interpret and analyze scientific data and work with cross functional teams to QC/communicate data in a timely manner

Present experimental results/updates at team meetings

Contribute to the management of the biology laboratory

Qualification

GPCR biologyCell-based assaysHTS screening methodologyVivo modelsOral communicationWritten communicationTeam collaborationFlexibility

Required

Bachelor's or master's degree in biochemistry, pharmacology, cell biology, or other related scientific areas with a minimum of 3-5 years of industry experience

Demonstrated scientific rigor with proven ability to critically evaluate data, and think independently and creatively in developing and testing new scientific hypotheses

Hands-on experience in cell biology and routine biological assays, including cell culture, HTRF and reporter gene cell-signaling assays, and imaging assays

Excellent oral and written communication skills is required

Highly motivated to work in a cross-functional team setting

Flexibility and ability to quickly learn new skills and knowledge on the job

Preferred

Hands-on experience with traditional and innovative screening methodologies for GPCRs, as well as concepts related to GPCR signaling and trafficking highly preferred

Familiarity with HTS screening methodology is highly desirable

Experience with design and implementation of in vivo models in coordination with CROs is highly desirable