Principal AI Researcher jobs in United States
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Synthesize Bio · 2 months ago

Principal AI Researcher

Synthesize Bio is an early stage startup focused on using generative AI to revolutionize life sciences research and enhance biomedical discovery. The Principal AI Researcher will lead generative AI research projects, develop and deploy foundational generative models for experimental biology data, and mentor junior team members while shaping the long-term technical vision of the AI/ML program.

Biotechnology
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Responsibilities

Lead the technical execution of key generative AI research projects
Develop, train, and deploy foundational generative models for experimental biology data into production
Help shape the AI/ML program's long-term technical vision
Provide technical guidance and mentorship to junior team members, including on other technical teams (e.g. software devs and computational biologists)
Lead innovative efforts in applying recent developments in the AI/ML literature to develop models that accelerate drug development
Successfully build and deploy generative foundation models for experimental biology
Actively contribute to technical vision and roadmap development
Set technical standards for model training, MLOps, and deployment in the cloud
Proactively collaborate with other teams to integrate AI models into the broader platform

Qualification

AI/ML model developmentGenerative modelsCloud platformsMLOpsNGS data knowledgeBiomedicine experienceModel deploymentTechnical leadershipCommunicationAdaptability

Required

Experience with developing AI/ML models to advance drug development or clinical research
Knowledge of NGS data (pre-clinical genomic or transcriptomic) or proteomic data
Experience training AI/ML models with AWS, Microsoft Azure, or Google Cloud Platform
Development experience with PyTorch, Tensorflow, JAX, or similar
Knowledge of key MLOps, including model training, hosted inference options, and batch/stream processing
Experience deploying AI/ML models in production environments
Proven track record of successfully developing AI/ML models in a relevant domain (e.g. biomedicine, life science, healthcare)
Demonstrated ability to lead technical projects, implement state-of-the-art research (e.g., generative models/diffusion/transformers), and deliver measurable results in a technically rigorous environment
Experience contributing to the technical vision and roadmap of an AI product or platform
Experience publishing in the AI/ML literature and implementing/developing new methodology based on research ideas
Focused on innovation and development rooted in practical applications
Open-minded and adaptable; willingness and ability to change focus and direction quickly in response to product/market demands
Comfortable working in close collaboration with the team and independently
Strong communication and desire to be a key player on a small, devoted team

Preferred

Experience fine-tuning and prompting Large Language Models
Experience managing model experimentation, development, and evaluation
Building models that are relevant to highly technical scientific domains
Understanding of or interest in computational genomics and applications of AI to biology

Benefits

100% employer paid health insurance premiums, 50% dependents
401k plan access (non-matching)
Gym access for Seattle-based employees

Company

Synthesize Bio

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Synthesize Bio uses AI to reduce data collection and analysis for a fraction of the cost in time, personnel, and materials.

Funding

Current Stage
Early Stage
Total Funding
$10M
Key Investors
Madrona
2025-09-16Seed· $10M
Company data provided by crunchbase