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Janux Therapeutics · 1 day ago

Senior Scientist, Protein Engineering (Phage Display)

San Diego County, CA

Full-time

Onsite

Mid, Senior Level

$144K/yr - $153K/yr

2+ years exp

Janux Therapeutics is seeking a highly skilled Senior Scientist in Protein Engineering to advance our innovative discovery programs. This role requires hands-on expertise with phage display platforms and antibody discovery and optimization techniques, and involves working independently and collaboratively in a fast-paced biotech environment.

BiotechnologyHealth DiagnosticsPharmaceuticalTherapeutics

Responsibilities

Design, construct, and quality check phage display libraries used in peptide and antibody-based screening campaigns targeting diverse antigens

Screen synthetic and immune phage libraries for high-affinity binders

Characterize peptide and antibody candidates using biochemical, biophysical, and cell-based assays (e.g., ELISA, BLI, flow cytometry)

Develop directed evolution libraries and execute screening methods to optimize peptide and antibody formats for improved affinity, stability, and developability

Collaborate with protein sciences and protein engineering teams to produce and validate peptide and antibody candidates

Analyze sequencing data from phage pools and selected clones to identify lead candidates

Maintain accurate and detailed experimental records and present findings in internal meetings

Contribute to patent filings, publications, and regulatory documentation as needed

Mentor junior scientists and contribute to a culture of scientific excellence and innovation

Perform other duties as assigned

Qualification

Phage display platformsAntibody discovery techniquesMolecular cloningLibrary designConstructionDNA sequencingCell-based expression systemsAnalytical tools ELISAAnalytical tools BLIExcel proficiencyMolecular biology softwareNext-generation sequencing3D modeling softwareProblem-solving skillsCollaboration skillsMentoring skills

Required

Ph.D. in Molecular Biology, Biochemistry, Immunology, or related field with 2+ years of relevant industry or postdoctoral experience (or M.S. with 5+ years at Scientist level)

Hands-on experience with phage display platforms and antibody selection techniques

Strong understanding of antibody structure-function relationships and engineering strategies

Proficiency in molecular cloning, library construction, sequencing, and cell-based expression systems (bacterial, yeast, mammalian)

Experience with analytical tools such as ELISA, liquid handler automation, plate-based assays, flow cytometry, and affinity measurements (SPR, BLI)

Excellent problem-solving skills and ability to work independently and collaboratively

Highly proficient with Excel and molecular biology software (e.g. Geneious)