Frontage Laboratories, Inc · 2 months ago
Senior Scientist/Principal Investigator-BioAnalytical Services
Exton, PA, US
Full-time
Onsite
Senior Level, Lead/Staff
1+ years expFrontage Laboratories, Inc. is a company focused on providing bioanalytical services, and they are seeking a Senior Scientist/Principal Investigator to develop quantitation methods for large molecules. The role involves method development, project management, and regulatory compliance while mentoring junior scientists and ensuring the quality of results for clients.
BiotechnologyClinical TrialsMedicalPharmaceuticalRobotics
Responsibilities
Mainly responsible for developing bioanalytical quantitation methods for large molecules in biological matrices using LC-MS/MS platform, including triple quadrupole and high-resolution MS instrument
Directly working with method development team head to design the experimental activities to address the bioanalytical challenges of the method, conduct the experiments, summarize the method development results, discussion with the team head of the experimental results and present the results internally and to sponsors
Simultaneously handle multiple method development projects or method qualification/method validation as required. Coordinate study activities with supervisor and internal team to ensure efficiency and quality of the projects within the timeline
Coordinate with internal team, like PI and PMs, to deliver the established methods to internal team for method validation and sample analysis within the expected timeline. Provide technical support and troubleshooting in cases the method performance does not meet the expectation
Maintain the proper level of regulatory compliance for each study, helping to address QC/QA audit findings
Keep track of industry trending on the quantitation of large molecules using LC-MS platform. Assess, evaluate and implement new technologies or instruments in the GLP labs to improve the analysis efficiency or data quality
Set-up, utilize, and maintain complex instrumentation Follow safety precautions
Responsible for all technical related discussion and method development
Routinely provide technical training to internal team. Serve as mentor for junior scientists in the team. Help with training and/or mentoring of junior scientific staff. Ensure that GLP regulations and SOPs are followed in all bioanalytical service activities
Maintain schedule of projects and timelines, communicate project timelines, status, and data to Principal Investigator effectively addressing any issues that may arise
Ability to work on multiple projects at the same time
Maintain tools, computer programs, and SOPs required for studies. Research literature and external sources and identify new techniques and procedures that strengthen Frontage’s capabilities
Work with support teams including sample management, lab support, metrology, QC, TW, PM & QA, BD as well as other PI’s and management to deliver quality results on time for clients
Qualification
Required
Prior working experience working large molecules, such as peptides, Oligos, mAbs, ADCs or sugar, lipids, etc
Prior working experience in triple quadrupole MS and High-Resolution MS instrument; Experience with Sciex QTOF instrument and/or Thermo Orbitrap Exploris 240 HRMS is a plus
Prior experience developing and validating bio-analytical methods for the quantitation of small molecules and large molecules in biological matrices using LC-MS/MS platform in a GLP lab
Experience using Sciex Analyst software, OS software, and Thermo Chromeleon and Watson LIMS is a plus
Quick learning capability and self-motivation
Flexible in the working schedule to meet the project timeline
Proven ability to successfully work in a team environment
Excellent oral and written communication skills
Understanding of experimental design and planning, data collection and summarize the experimental results and presentation skills, and familiar with common data analysis software
Ph.D. in Analytical Chemistry, Biochemistry, Pharmacology or related scientific discipline with 1-2+ years direct experience, OR Master's degree in same disciplines with 2-4+ years direct experience in large molecules quantitation field using LC-MS/MS platform, OR Bachelor's degree in same discipline with 5+ years direct experience in large molecules quantitation field using LC-MS/MS platform
Preferred
Experience with Sciex QTOF instrument and/or Thermo Orbitrap Exploris 240 HRMS is a plus
Experience using Sciex Analyst software, OS software, and Thermo Chromeleon and Watson LIMS is a plus
Benefits
Health and dental insurance
A 401(k) plan
Health insurance
Short and long-term disability insurance
Life insurance
Company
Frontage Laboratories, Inc
Frontage Laboratories is a US-based Contract Research Organization (CRO) that was initially established in New Jersey in April 2001 and later relocated to Pennsylvania in 2004.
1001-5000 employees
H1B Sponsorship
Frontage Laboratories, Inc has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (38)
2024 (37)
2023 (24)
2022 (29)
2021 (34)
2020 (45)
Funding
Current Stage
Public CompanyTotal Funding
$42.37MKey Investors
Baird Capital
2019-05-30IPO
2018-03-01Undisclosed· $32.37M
2014-05-08Acquired
Leadership Team
Song Li
CEO
Abdul Mutlib
Vice President
Recent News
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