Eli Lilly and Company · 2 weeks ago
Scientist - Mass Spectrometry
Boston, MA
Full-time
Onsite
Entry, Mid Level
$71K/yr - $187K/yr
2+ years expEli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, dedicated to improving lives through innovative medicines. They are seeking an experienced analytical scientist to develop and troubleshoot analytical methods for characterizing small molecules and biologics, with a focus on mass spectrometry and liquid chromatography techniques.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Work closely with the chemistry team to source, explore, and implement the latest separation science and analytical technologies for the purification and characterization of oligonucleotides and their conjugates, including carbohydrates, lipids, peptides, and proteins
Conduct LC and LC-MS based method development for sensitive characterization of biologics including intact mass, reduced mass, peptide mapping, and glycan mapping to provide better understanding of attributes
Conduct semi-preparative and preparative method development activities to advance downstream processing for challenging modified oligonucleotides, utilizing RP purification, ion-exchange chromatography, spin filtration, TFF, FPLC, size exclusion chromatography, and MS-direct auto-scale preparative LC-MS techniques
Work with contractors and third-party vendors to troubleshoot and maintain lab instruments, including but not limited to UPLC, LC-MS, osmometer, and NanoDrop, ensuring they remain in peak operational condition
Learn new technologies quickly and apply effective scientific concepts and methods across multiple areas
Process and present data leveraging Microsoft Office apps, GraphPad and Spotfire for data organization and data visualization
Document experiments, data, technical reports, and findings electronically in an accessible manner with good documentation practices
Present findings, progress, and data proactively and regularly in group and department meetings
Possess a collaborative and willing-to-share mindset with excellent verbal and written communication skills, presentation skills, and attention to detail
Ability to follow Global Health, Safety & Environment Center (HSE) guidelines while performing tasks
Qualification
Required
Bachelor's or Master's degree in Analytical Chemistry, Biochemistry, Chemistry, Food Science, or a related scientific field, with over 2 years of relevant post-graduate experience in industry
Extensive hands-on experience in analytical techniques for characterizing and analyzing small molecules, biologics, and/or oligonucleotides
Proven track record in analytical method development and troubleshooting
Experience with liquid chromatography, (high resolution) mass spectrometry, and other advanced analytical techniques
Strong technical problem-solving skills
Computer savvy with the ability to navigate multiple instrument control programs and data analysis environments
Ability to work independently to achieve efficient, quality results in a fast-paced environment
Ability to follow Global Health, Safety & Environment Center (HSE) guidelines while performing tasks
Preferred
Strong analytical thinking skills with a demonstrated ability to articulate issues and extract and synthesize complex information into key focus areas
Extensive experience in operating and troubleshooting a range of mass spectrometers including Q-ToF, QQQ and Orbitrap
Proficient with Thermo XCalibur, Agilent ChemStation and MassHunter software
Understanding tandem mass spectrometry and interpretation of MS/MS based characterization including but not limited to peptide, peptide-oligonucleotide conjugates, and lipid conjugates
Extensive hands-on experience in downstream workflows for small molecules, biologics, and oligonucleotides. Experience with antibody-drug-conjugates (ADCs) or antibody-oligonucleotide-conjugates (AOCs) is a plus
Proven expertise in liquid chromatography including ion-pair reverse phase liquid chromatography as well as ion chromatography
Prior experience in native mass spectrometry and understanding of electrospray ionization as well as molecular behavior in the gas phase
Prior experience in proteomics, bioanalysis, and/or CMC is a significant advantage
Highly self-motivated and self-driven attitude with ability to own and drive projects into success
Strong organizational and communication skills and effective people skills
Capable of continuous learning, open-minded, highly organized, and detail oriented
Ability to balance multiple activities, prioritize and handle ambiguity
Benefits
Eligibility to participate in a company-sponsored 401(k)
Pension
Vacation benefits
Eligibility for medical, dental, vision and prescription drug benefits
Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
H1B Sponsorship
Eli Lilly and Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (514)
2024 (236)
2023 (167)
2022 (133)
2021 (57)
2020 (52)
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
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2026-01-25
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