Regeneron · 2 months ago
Senior Scientist (Oligonucleotide Therapeutics)
TARRYTOWN
Full-time
Onsite
Mid, Senior Level
$108K/yr - $177K/yr
2+ years expRegeneron Pharmaceuticals is seeking a highly skilled and motivated Senior Scientist to join their group dedicated to drug discovery and technology development in oligonucleotide therapeutics. The role involves designing and screening oligonucleotide candidates and conducting research to improve the chemistry and delivery of nucleic acid therapeutics.
BiopharmaBiotechnologyPharmaceutical
Responsibilities
Maintaining and culturing cell lines and primary cells, as well as generating stable cell lines
Optimiassays to test oligonucleotide drug candidates such as siRNAs/ASOs using both cell-based activity assays (cell migration, viability, microscopy, flow cytometry, etc.) and RNA based activity assays (RT-qPCR, RISC loading, RNaseH cleavage)
Running and analyzing off-target profiles, propose optimizations, and design PK/PD, stability and metabolic profiling assays
Carrying out routine molecular biology and biochemistry tasks including PCR, western blot, etc
Optimizing and implementing protocols to test for novel delivery techniques for oligonucleotides based on antibodies, peptides and other conjugates
Work on developing tissue specific delivery platforms for nucleic acid therapeutics
Work closely with the synthetic chemistry group to optimize chemistry of nucleic acid drug candidates
Qualification
Required
Ph.D
2+ years of relevant experience in siRNA/gene therapy space
Experience working with siRNA/ASOs
In-depth knowledge in gene transcription and protein translation
Knowledge of RNA splicing
Knowledge of gene expression regulation
Experience in cell-based screening assays, such as ELISA, luciferase, fluorescence and Western blotting
Experience in flow cytometry
RT-qPCR skills
Experience with cell culture
Preferred
Experience in flow cytometry and bDNA assays
Experience working in-vivo and genotyping
Generating stable cell lines with various viral vectors (retrovirus, lentivirus, adeno-associated virus, etc)
Experience in bioconjugation
Experience working with chromatography systems for biomolecule purifications
Benefits
Health and wellness programs (including medical, dental, vision, life, and disability insurance)
Fitness centers
401(k) company match
Family support benefits
Equity awards
Annual bonuses
Paid time off
Paid leaves (e.g., military and parental leave)
Company
Regeneron
Regeneron Pharmaceuticals specializes in the discovery, development, and commercialization of innovative medicines.
10001+ employees
H1B Sponsorship
Regeneron has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (157)
2024 (128)
2023 (128)
2022 (137)
2021 (104)
2020 (122)
Funding
Current Stage
Public CompanyTotal Funding
$15.93MKey Investors
U.S. Department of Health & Human Services
2024-07-11Post Ipo Equity· $2.03M
2023-10-18Post Ipo Equity· $5M
2016-08-22Post Ipo Equity· $8.9M
Leadership Team
Aris Baras
Senior Vice President, Regeneron Pharmaceuticals, General Manager, Regeneron Genetics Center
Bari Kowal
Senior Vice President, Head Development Operations & Portfolio Management
Recent News
Pharmaceutical Technology
2026-01-16
2026-01-16
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